We present multiwavelength observations of the tidal disruption event (TDE) iPTF15af, discovered by the intermediate Palomar Transient Factory survey at redshift z = 0.07897. The optical and ...ultraviolet (UV) light curves of the transient show a slow decay over 5 months, in agreement with previous optically discovered TDEs. It also has a comparable blackbody peak luminosity of . The inferred temperature from the optical and UV data shows a value of (3-5) × 104 K. The transient is not detected in X-rays up to within the first 5 months after discovery. The optical spectra exhibit two distinct broad emission lines in the He ii region, and at later times also H emission. Additionally, emission from N iii and O iii is detected, likely produced by the Bowen fluorescence effect. UV spectra reveal broad emission and absorption lines associated with high-ionization states of N v, C iv, Si iv, and possibly P v. These features, analogous to those of broad absorption line quasars (BAL QSOs), require an absorber with column densities cm−2. This optically thick gas would also explain the nondetection in soft X-rays. The profile of the absorption lines with the highest column density material at the largest velocity is opposite that of BAL QSOs. We suggest that radiation pressure generated by the TDE flare at early times could have provided the initial acceleration mechanism for this gas. Spectral UV line monitoring of future TDEs could test this proposal.
Habitat availability determines the distribution of migratory waterfowl along their flyway, which further influences the transmission and spatial spread of avian influenza viruses (AIVs). The ...extensive habitat loss in the East Asian-Australasian Flyway (EAAF) may have potentially altered the virus spread and transmission, but those consequences are rarely studied. We constructed 6 fall migration networks that differed in their level of habitat loss, wherein an increase in habitat loss resulted in smaller networks with fewer sites and links. We integrated an agent-based model and a susceptible-infected-recovered model to simulate waterfowl migration and AIV transmission. We found that extensive habitat loss in the EAAF can 1) relocate the outbreaks northwards, responding to the distribution changes of wintering waterfowl geese, 2) increase the outbreak risk in remaining sites due to larger goose congregations, and 3) facilitate AIV transmission in the migratory population. In addition, our modeling output was in line with the predictions from the concept of “migratory escape”, i.e., the migration allows the geese to “escape” from the location where infection risk is high, affecting the pattern of infection prevalence in the waterfowl population. Our modeling shed light on the potential consequences of habitat loss in spreading and transmitting AIV at the flyway scale and suggested the driving mechanisms behind these effects, indicating the importance of conservation in changing spatial and temporal patterns of AIV outbreaks.
The optical and optical/near-infrared pseudo-bolometric light curves of 85 stripped-envelope supernovae (SNe) are constructed using a consistent method and a standard cosmology. The light curves are ...analysed to derive temporal characteristics and peak luminosity L
p, enabling the construction of a luminosity function. Subsequently, the mass of 56Ni synthesized in the explosion, along with the ratio of ejecta mass to ejecta kinetic energy, are found. Analysis shows that host-galaxy extinction is an important factor in accurately determining luminosity values as it is significantly greater than Galactic extinction in most cases. It is found that broad-lined SNe Ic (SNe Ic-BL) and gamma-ray burst SNe are the most luminous subtypes with a combined median L
p, in erg s−1, of log(L
p) = 43.00 compared to 42.51 for SNe Ic, 42.50 for SNe Ib, and 42.36 for SNe IIb. It is also found that SNe Ic-BL synthesize approximately twice the amount of 56Ni compared with SNe Ic, Ib, and IIb, with median M
Ni = 0.34, 0.16, 0.14, and 0.11 M⊙, respectively. SNe Ic-BL, and to a lesser extent SNe Ic, typically rise from L
p/2 to L
p more quickly than SNe Ib/IIb; consequently, their light curves are not as broad.
Millisecond-duration bright radio pulses at 1.4 GHz with high dispersion measures (DMs) were reported by Lorimer et al., Keane et al., and Thornton et al. Their all-sky rate is approximately 10 ...super(4) day super(-1) above ~1 Jy. Related events are "Perytons"-similar pulsed, dispersed sources, but most certainly local. Suggested models of fast radio bursts (FRBs) can originate in Earth's atmosphere, in stellar coronae, in other galaxies, and even at cosmological distances. Using physically motivated assumptions combined with observed properties, we explore these models. In our analysis, we focus on the Lorimer event: a 30 Jy, 5 ms duration burst with DM = 375 cm super(-3) pc, exhibiting a steep frequency-dependent pulse width (the Sparker). To be complete, we drop the assumption that high DMs are produced by plasma propagation and assume that the source produces pulses with frequency-dependent arrival time ("chirped signals"). Within this framework, we explore a scenario in which Perytons, the Sparker, and the FRBs are all atmospheric phenomena occurring at different heights. This model is ad hoc in that we cannot explain why Perytons at higher altitudes show greater DMs or exhibit narrower pulses. Nonetheless, we argue that the Sparker may be a Peryton. We end with two remarks. First, the detection of a single FRB by an interferometer with a kilometer (or longer) baseline will prove that FRBs are of extraterrestrial origin. Second, we urge astronomers to pursue observations and understanding of Perytons since they form (at least) a formidable foreground for the FRBs.
Using the Murchison Widefield Array (MWA), the low-frequency Square Kilometre Array precursor located in Western Australia, we have completed the GaLactic and Extragalactic All-sky MWA (GLEAM) ...survey, and present the resulting extragalactic catalogue, utilizing the first year of observations. The catalogue covers 24 831 square degrees, over declinations south of +30... and Galactic latitudes outside 10... of the Galactic plane, excluding some areas such as the Magellanic Clouds. It contains 307 455 radio sources with 20 separate flux density measurements across 72-231 MHz, selected from a time- and frequency-integrated image centred at 200 MHz, with a resolution of ...2 arcmin. Over the catalogued region, we estimate that the catalogue is 90 per cent complete at 170 mJy, and 50 per cent complete at 55 mJy, and large areas are complete at even lower flux density levels. Its reliability is 99.97 per cent above the detection threshold of 5..., which itself is typically 50 mJy. These observations constitute the widest fractional bandwidth and largest sky area survey at radio frequencies to date, and calibrate the low-frequency flux density scale of the southern sky to better than 10 per cent. This paper presents details of the flagging, imaging, mosaicking and source extraction/characterization, as well as estimates of the completeness and reliability. All source measurements and images are available online. This is the first in a series of publications describing the GLEAM survey results. (ProQuest: ... denotes formulae/symbols omitted.)
Background and Objective
The oral microbiome may help to maintain systemic health, including how it affects blood glucose levels; however, direct evidence linking the oral microbiome with diabetes is ...lacking.
Material and Methods
We compared the oral microbiome profiles of 98 participants with incident diabetes, 99 obese non‐diabetics and 97 normal weight non‐diabetics, via deep sequencing of the 16S rRNA gene.
Results
We found that the phylum Actinobacteria was present significantly less abundant among patients with diabetes than among the controls (p = 3.9 × 10−3); the odds ratio (OR) and 95% confidence interval (CI) was 0.27 (0.11–0.66) for those individuals who had relative abundance higher than the median value. Within this phylum, five families and seven genera were observed, and most of them were less abundant among patients with diabetes. Notably, genera Actinomyces and Atopobium were associated with 66% and 72% decreased risk of diabetes with p‐values of 8.9 × 10−3 and 7.4 × 10−3, respectively. Stratified analyses by race showed that most taxa in this phylum were associated with diabetes in both black and white participants. This phylum was also less abundant among non‐diabetic obese subjects compared to normal weight individuals, particularly genera Mobiluncus, Corynebacterium and Bifidobacterium, which showed p < 0.05.
Conclusion
Our study revealed that multiple bacteria taxa in the phylum Actinobacteria are associated with the risk of type 2 diabetes. Some are also associated with the prevalence of obesity, suggesting that the oral microbiome may play an important role in diabetes etiology.
The recently discovered fast radio bursts (FRBs), presumably of extragalactic origin, have the potential to become a powerful probe of the intergalactic medium (IGM). We point out a few such ...potential applications. We provide expressions for the dispersion measure and rotation measure as a function of redshift, and we discuss the sensitivity of these measures to the He II reionization and the IGM magnetic field. Finally, we calculate the microlensing effect from an isolated, extragalactic stellar-mass compact object on the FRB spectrum. The time delays between the two lensing images will induce constructive and destructive interference, leaving a specific imprint on the spectra of FRBs. With a high all-sky rate, a large statistical sample of FRBs is expected to make these applications feasible.
The registration data of local cancer registries in 2014 were collected by National Central Cancer Registry (NCCR)in 2017 to estimate the cancer incidence and mortality in China.
The data submitted ...from 449 registries were checked and evaluated, and the data of 339 registries out of them were qualified and selected for the final analysis. Cancer incidence and mortality were stratified by area, gender, age group and cancer type, and combined with the population data of 2014 to estimate cancer incidence and mortality in China. The age composition of standard population of Chinese census in 2000 and Segi's population were used for age-standardized incidence and mortality in China and worldwide, respectively.
Total covered population of 339 cancer registries (129 in urban and 210 in rural) in 2014 were 288 243 347 (144 061 915 in urban and 144 181 432 in rural areas). The mortality verified cases (MV%) were 68.01%. Among them, 2.19% cases were identified through death certifications only (DCO%), and the mortality
Without a virus culture system, genetic analysis becomes the principal method to classify norovirus (NoV) strains. Currently, classification of NoV strains beneath the species level has been based on ...sequences from different regions of the viral genome. As a result, the phylogenetic insights of some virus were not appropriately interpreted, and no consensus has been reached to establish a uniform classification scheme. To provide a consistent and reliable scientific basis for classifying NoVs, we analyzed the amino acid sequences for the major capsid protein of 164 NoV strains by first using an alignment based on the predicted 3D structures. A Bayesian tree was generated, and the maximum likelihood pairwise distances of the aligned sequences were used to evaluate the results from the uncorrected pairwise distance method. Analyses of the pairwise distances demonstrated three clearly resolved peaks, suggesting that NoV strains beneath the species level can be classified at three levels: strain (S), cluster (C), and genogroup (G). The uncorrected pairwise distance ranges for S, C, and G were 0–14.1%, 14.3–43.8%, and 44.9–61.4%, respectively. A scheme with 29 genetic clusters 8 in genogroup 1 (G1), 17 in G2, 2 in G3, and 1 each in G4 and G5 was defined on the basis of the tree topology with the standards provided and was supported by the distance analysis. Of these, five clusters in G2 and one in G1 are newly described. This analysis can serve as the basis for a standardized nomenclature to genetically describe NoV strains.
Though antibiotic resistance (ABR) represents a major global health threat, contributions of landfill leachate to the life cycle of antibiotics and ABR development are poorly understood in rapidly ...urbanizing regions of developing countries. We selected one of the largest active landfills in Asia and two landfills that have been closed for 20 years to examine antibiotic occurrences in leachates and associated hazards during wet and dry season sampling events. We focused on some of the most commonly used human antibiotics in Hong Kong, one of the most populous Asian cities and the fourth most densely populated cities in the world. Seven antibiotics (cephalexin CLX, chloramphenicol CAP, ciprofloxacin CIP, erythromycin ERY, roxithromycin ROX, trimethoprim TMP, sulfamethoxazole SMX) were quantitated using HPLC-MS/MS generally following previously reported methods. Whereas CLX, CAP, ROX and SMX in leachates did not exceed ABR predicted no effect concentrations (PNECs), exceedances were observed for CIP, ERY and TMP in some study locations and on some dates. In fact, an ABR PNEC for CIP was exceeded in leachates during both sampling periods from all study locations, including leachates that are directly discharged to coastal systems. These findings highlight the importance of developing an advanced understanding of pharmaceutical access, usage and disposal practices, effectiveness of intervention strategies (e.g., leachate treatment technologies, drug take-back schemes), and contributions of landfill leachates to the life cycle of antibiotics and ABR development, particularly in rapidly urbanizing coastal regions with less advanced waste management systems than Hong Kong.
•CIP & ERY levels in raw leachate from landfill closed for 20 years are very high.•The PNECs for resistance selection of CIP, ERY & TMP have been exceeded.•This poses threats to the development of antibiotic resistance in HK waters.•Policy intervention in the form of a drug take-back scheme is warranted.
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