To observe the effects of sacral canal injection in treating lumbar intervertebral disc herniation with different sections, types and courses, in order to provide selective basis for clinical ...indications.
From March 2007 to May 2011, 329 patients with lumbar intervertebral disc herniation were treated with sacral canal injection and their data were retrospectively analyzed. There were 178 males and 151 females,ranging in age from 16 to 78 years old with an average of 45 years; ranging in course of disease from 2 days to 41 years with an average of 4.1 years. All the protrusions were simple segment, and L3,4 of 51 cases, L4,5 of 142 cases, L5S1 of 136 cases including central protrusion of 137 cases, posterolateral of 145 cases, extreme posterolateral of 47 cases. According to different sections, types, courses (more than or less than 6 months ) of lumbar intervertebral disc herniation, the patients were divided into several groups, clinical effects of the groups were compared and analyzed.
Clinical effect of p
In the present study, an ultra performance liquid chromatography coupled with time-of-fight mass spectrometry (UPLC-TOF/MS) based chemical profiling approach was used to evaluate chemical ...constitution between co-decoction and mixed decoction of ginseng and Radix Aconiti Praeparata. Two different kinds of decoctions, namely co-decoction of ginseng and Radix Aconiti Praeparata: water extract of mixed two herbs, and mixed decoction of ginseng and Radix Aconiti Praeparata: mixed water extract of each individual herbs, were prepared. Batches of these two kinds of decoction samples were subjected to UPLC-TOF/MS analysis. The datasets of t(R) m/z pairs, ion intensities and sample codes were processed with supervised partial least squared discriminant analysis (OPLS-DA) to holistically compare the difference between these two decoction samples. Significant difference between the two decoction samples was showed in the results of positive ion mode. The contents of hypaconitine and deoxyaconitine decreased, while that
Phytochemical investigation on the stems of Kadsura renchangiana led to the isolation of two new sesquiterpenoids, renchangianins F and G (1 and 2). Their structures were elucidated by spectroscopic ...methods, including 2D NMR techniques. The in vitro cytotoxic activities of the isolates were studied against HepG2, A549, and LN229 cancer cell lines.
Glutathione S-transferase A1 (GSTA1) appears to be primarily involved in detoxification processes, but possible roles in lung cancer remain unclear. The objective of this study was to investigate the ...expression and function of GSTA1 in lung cancer cells. Real-time PCR and Western blotting were performed to assess expression in cancer cell lines and the normal lung cells, then verify the A549 cells line with stable overexpression. Localization of GSTA1 proteins was assessed by cytoimmunofluorescence. Three double-strand DNA oligoRNAs (SiRNAs) were synthesized prior to being transfected into A549 cells with Lipofectamine 2000, and then the most efficient SiRNA was selected. Expression of the GSTA1 gene in the transfected cells was determined by real-time PCR and Western blotting. The viability of the transfected cells were assessed by MTT. Results showed that the mRNA and protein expression of A549 cancer cells was higher than in MRC-5 normal cells. Cytoimmunofluorescence demonstrated GSTA1 localization in the cell cytoplasm and/or membranes. Transfection into A549 cells demonstrated that down-regulated expression could inhibit cell viability. Our data indicated that GSTA1 expression may be a target molecule in early diagnosis and treatment of lung cancer.
Strong light–matter interactions in low-dimensional materials offer an opportunity for flexible property-tuning by optical switching. Herein, we exploit photoexcitation for spin injection into ...semiconductors by rationally designing heterojunctions having distinct dynamic behavior for photocarriers in two spin channels. As a proof-of-concept, we trigger homogeneous magnetism in a group III monochalcogenide monolayer (MX with M = In, Ga; X = S, Se) by placing it on a ferromagnetic CrI3 substrate under light illumination. Our time-dependent ab initio nonadiabatic molecular dynamics simulations reveal fast electron–hole separation for the majority spin channel but rapid recombination for the minority spin channel at this heterostructure. The majority carriers cause hole doping and strong ferromagnetic ordering in the MX sheet, with magnetic moment tunable by the injected carriers’ concentration. The interplay between photoexcited hole carriers, the Van Hove singularity of MX monolayers, and interfacial charge transfer provides essential physical insights for nondestructively manipulating charge and spin in two-dimensional semiconductors via light switching.
Structural and elastic properties of La2Mg17 with layer structure have been investigated within framework of the density functional theory. Different from the general layer-structured materials, the ...obtained c/a is less than unity. The calculated elastic constants C33 is larger than C11, being novel in comparison with other alloys with layer structure. The calculated bulk, shear and Young’s modulus of La2Mg17 are higher than other Mg–La alloys with higher La content, implying the stronger covalent bonding. Moreover, the elastic isotropies of La2Mg17 are more excellent. The electronic structure within basal plane is highly symmetric, and the electronic interaction within basal plane is slightly weaker than one between basal planes, which reveal the underlying mechanism for the structural and elastic properties of La2Mg17.
The crystal structure (a) and the atomic positions for (b) (0002), (c) (0004) and (d) (12¯10) plane of La2Mg17. Display omitted
•The c/a of La2Mg17 is anomalously less than unity.•It is novel that for La2Mg17 the elastic constants C33 is larger than C11.•The elastic modulus of La2Mg17 is higher than other Mg–La alloys.•The elastic isotropy of La2Mg17 is excellent.•The electronic structure within basal plane is highly symmetric.
In this study, a GC-MS technique was applied to determine 17α-ethinylestradiol (EE2), an active ingredient of oral contraceptives, and its fate in Lake Quinsigamond, Massachusetts, USA. To the ...knowledge of the authors, this is the first study of EE2 and its microbial and photochemical degradation in a lake ecosystem. EE2 was detected at a concentration up to 11.1 ng L(-1). At this concentration EE2 may affect the reproduction of fish and other aquatic organisms in the lake due to its high estrogenic activity. EE2 was persistent to the biodegradation by the microorganisms in the lake. Under aerobic conditions a long lag phase (42 days) was observed before the biodegradation of EE2 and a half-life of 108 days was estimated. Under anaerobic conditions, EE2 experienced even a longer acclimation stage (63 days) and a slower microbial degradation in the lake water. The photodegradation of EE2 was rapid in the lake surface water under natural sunlight, with a half-life of less than 2 days in summer sunny days. Compared to biodegradation, photodegradation may represent a predominant removal mechanism for EE2 in natural surface waters.
Precisely regulating the electronic structures of metal active species is highly desirable for electrocatalysis. However, carbon with inert surface provide weak metal–support interaction, which is ...insufficient to modulate the electronic structures of metal nanoparticles. Herein, we propose a new method to control the electrocatalytic behavior of supported metal nanoparticles by dispersing single metal atoms on an O‐doped graphene. Ideal atomic metal species are firstly computationally screened. We then verify this concept by deposition of Ru nanoparticles onto an O‐doped graphene decorated with single metal atoms (e.g., Fe, Co, and Ni) for hydrogen evolution reaction (HER). Consistent with theoretical predictions, such hybrid catalysts show outstanding HER performance, much superior to other reported electrocatalysts such as the state‐of‐the‐art Pt/C. This work offers a new strategy for modulating the activity and stability of metal nanoparticles for electrocatalysis processes.
Carbon‐based substrates with an inert surface provide weak metal–support interactions that are insufficient to effectively modulate the electronic structures of the loaded metal nanoparticles. Here we show that atomic metal species on the carbon substrate can remotely communicate with the supported metal nanoparticles, inducing synergistic electronic coupling with the nanoparticles and enabling the control of their electrocatalytic activity.
Whether acupuncture is effective for patients with functional constipation is still unclear. Therefore, we report the protocol of a randomized controlled trial of using acupuncture to treat ...functional constipation.
A randomized, controlled, four-arm design, large-scale trial is currently undergoing in China. Seven hundred participants are randomly assigned to three acupuncture treatment groups and Mosapride Citrate control group in a 1:1:1:1 ratio. Participants in acupuncture groups receive 16 sessions of acupuncture treatment, and are followed up for a period of 9 weeks after randomization. The acupuncture groups are: (1) Back-Shu and Front-Mu acupoints of Large Intestine meridians (Shu-Mu points group); (2) He-Sea and Lower He-Sea acupoints of Large Intestine meridians (He points group); (3) Combining used Back-Shu, Front-Mu, He-Sea, and Lower He-Sea acupoints of Large Intestine meridians (Shu-Mu-He points group). The control group is Mosapride Citrate group. The primary outcome is frequency of defecation per week at the fourth week after randomization. The secondary outcomes include Bristol stool scale, the extent of difficulty during defecating, MOS 36-item Short Form health survey (SF-36), Self-Rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). The first two of second outcomes are measured 1 week before randomization and 2, 4, and 8 weeks after randomization. Other second outcomes are measured 1 week before randomization and 2 and 4 weeks after randomization, but SF-36 is measured at randomization and 4 weeks after randomization.
The result of this trial (which will be available in 2012) will confirm whether acupuncture is effective to treat functional constipation and whether traditional acupuncture theories play an important role in it.
Clinical Trials.gov NCT01411501.
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