Abstract
Recent progress in algal biotechnology has identified new products based on their broad evolutionary origin. Novel metabolites were found for pharmacy, food industry, medicine e.g. tumor ...suppression and antibiotics. However, sustainable and economical algal production for crude oil replacement is limited by extremely low space time yields in photobioreactors. The consequences are a high energy burden for mass flow dependent processes and the need of space being in conflict with sustainable landscape management. New concepts using algae not as biomass producers but as living catalysts may open new options.
Abstract
Vitamins play an important role in many processes in the human organism. The detection of insufficient supply of vitamins is therefore of particular importance to avoid significant effects ...for human health. An increasing number of tests is only possible with suitable automated procedures. For the determination of vitamin D3 and vitamin D2 in serum samples, three methods were automated and compared with regard to their performance. All three methods enable reliable detection of 25(OH)D2 and 25(OH)D3 in serum in the ng/ml range.
Abstract
Since decades antibodies are used for diagnosis e. g. by detecting patient antibodies that specifically bind to Influenza virus proteins. We predict these diagnostic questions will be ...parallelized to diagnose all known disease specific antibodies at once. These tests will ask in addition, which unknown antibodies patrol in a patient’s blood, and what exactly they bind to. Thereby, we expect to find antibody species that correlate to hitherto enigmatic diseases or have specialized functions.
Abstract
Polyketides (PKs) are secondary metabolites with valuable properties, including antibiotic, antifungal, antiviral, anticancer, and immunosuppressive activity. The biosynthesis of PKs is ...accomplished by multifunctional megaenzymes, the polyketide synthases (PKSs). The molecular architecture of those remarkable assembly lines provides opportunities for their engineering and generation of PK derivatives with potentially improved pharmacokinetics and/or expanded spectrum of bioactivity.
Who is liable if self-spreading biotechnology causes transboundary harm? With engineered gene drives and similar techniques, the genes of wild-living species, pathogens, and crop plants can soon be ...modified directly in the environment. This might help address pressing public health, environmental, and food security problems. However, these techniques may also spread across national borders. Looking at both states and private actors, this book studies the rules of international law on the prevention of, and liability for, adverse transboundary effects caused by self-spreading biotechnology. Through an in-depth analysis of the relevant treaties and custom, it shows that international law is not yet equipped to cope with the challenges ahead.
Focusing on the period between the 1970s and the present, Life as Surplus is a pointed and important study of the relationship between politics, economics, science, and cultural values in the United ...States today. Melinda Cooper demonstrates that the history of biotechnology cannot be understood without taking into account the simultaneous rise of neoliberalism as a political force and an economic policy. From the development of recombinant DNA technology in the 1970s to the second Bush administration's policies on stem cell research, Cooper connects the utopian polemic of free-market capitalism with growing internal contradictions of the commercialized life sciences.
The biotech revolution relocated economic production at the genetic, microbial, and cellular level. Taking as her point of departure the assumption that life has been drawn into the circuits of value creation, Cooper underscores the relations between scientific, economic, political, and social practices. In penetrating analyses of Reagan-era science policy, the militarization of the life sciences, HIV politics, pharmaceutical imperialism, tissue engineering, stem cell science, and the pro-life movement, the author examines the speculative impulses that have animated the growth of the bioeconomy.
At the very core of the new post-industrial economy is the transformation of biological life into surplus value. Life as Surplus offers a clear assessment of both the transformative, therapeutic dimensions of the contemporary life sciences and the violence, obligation, and debt servitude crystallizing around the emerging bioeconomy.
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Shape-shifting of flat materials into the desired 3D configuration is an alternative design route for fabrication of complex 3D shapes, which provides many benefits such as access to ...the flat material surface and the ability to produce well-described motions. The advanced production techniques that primarily work in 2D could then be used to add complex surface features to the flat material. The combination of complex 3D shapes and surface-related functionalities has a wide range of applications in biotechnology, actuators/sensors, and engineering of complex metamaterials. Here, we categorize the different programming strategies that could be used for planning the shape-shifting of soft matter based on the type of stresses generated inside the flat material and present an overview of the ways those mechanisms could be used to achieve the desired 3D shapes. Stress gradients through the thickness of the material, which generate out-of-plane bending moments, and compressive in-plane stresses that result in out-of-plane buckling constitute the major mechanisms through which shape-shifting of the flat matter could be programmed. We review both programming strategies with a focus on the underlying physical principles, which are highly scalable and could be applied to other structures and materials. The techniques used for programming the time sequence of shape-shifting are discussed as well. Such types of so-called “sequential” shape-shifting enable achieving more complex 3D shapes, as the kinematics of the movements could be planned in time to avoid collisions. Ultimately, we discuss what 3D shapes could be achieved through shape-shifting from flat soft matter and identify multiple areas of application.
Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic ...technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.
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