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  • Short-chain fatty acids act... Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines
    Cox, Mary Ann; Jackson, James; Stanton, Michaela ... World journal of gastroenterology : WJG, 11/2009, Volume: 15, Issue: 44
    Journal Article

    AIM: To investigate the effect of short-chain fatty acids (SCFAs) on production of prostaglandin E2 (PGE2), cytokines and chemokines in human monocytes. METHODS: Human neutrophils and monocytes were ...
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22.
  • Physical characterization a... Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting
    Telikepalli, Srivalli; Shinogle, Heather E; Thapa, Prem S ... Journal of pharmaceutical sciences, 20/May , Volume: 104, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    An IgG2 monoclonal antibody (mAb) solution was subjected to stirring, generating high concentrations of nanometer and subvisible particles, which were then successfully size-enriched into different ...
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23.
  • Inflammatory Determinants o... Inflammatory Determinants of Pregravid Obesity in Placenta and Peripheral Blood
    Sureshchandra, Suhas; Marshall, Nicole E; Wilson, Randall M ... Frontiers in physiology, 08/2018, Volume: 9
    Journal Article
    Peer reviewed
    Open access

    Pre-pregnancy (pregravid) obesity has been linked to several adverse health outcomes for both mother and offspring. Complications during pregnancy include increased risk for gestational diabetes, ...
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24.
  • Immune and inflammatory res... Immune and inflammatory responses of human macrophages, dendritic cells, and T-cells in presence of micro- and nanoplastic of different types and sizes
    Wolff, Christina M.; Singer, Debora; Schmidt, Anke ... Journal of hazardous materials, 10/2023, Volume: 459
    Journal Article
    Peer reviewed

    Environmental pollution by microplastics (MPs) is a growing concern regarding their impact on aquatic and terrestrial systems and human health. Typical exposure routes of MPs are dermal contact, ...
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25.
  • MIF promotes a differential... MIF promotes a differential Th1/Th2/Th17 inflammatory response in human primary cell cultures: Predominance of Th17 cytokine profile in PBMC from healthy subjects and increase of IL-6 and TNF-α in PBMC from active SLE patients
    De la Cruz-Mosso, Ulises; García-Iglesias, Trinidad; Bucala, Richard ... Cellular immunology, February 2018, 2018-02-00, 20180201, Volume: 324
    Journal Article
    Peer reviewed

    •MIF promotes a differential Th1/Th2/Th17 inflammatory response in PBMC cultures.•PBMCs from healthy subjects showed a predominance of Th17 cytokine profile.•PBMCs from active SLE patients showed an ...
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26.
  • Immunophenotyping, Part II: Analysis of Nanoparticle Effects on the Composition and Activation Status of Human Peripheral Blood Mononuclear Cells
    Newton, Hannah S; Zhang, Jenny; Dobrovolskaia, Marina A Methods in molecular biology (Clifton, N.J.), 2024, Volume: 2789
    Journal Article

    The use of nanoparticles as drug delivery carriers requires analysis of their safety, which among other tests, includes immunotoxicity. Nanoparticles are also increasingly used for applications ...
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27.
  • Mitochondrial-mediated infl... Mitochondrial-mediated inflammation and platelet activation in giant cell arteritis
    Michailidou, Despina; Grayson, Peter C.; Hermanson, Payton ... Clinical immunology (Orlando, Fla.), October 2023, 2023-10-00, 20231001, Volume: 255
    Journal Article
    Peer reviewed
    Open access

    Markers of extracellular mitochondria are present in giant cell arteritis (GCA) patients. However, their role in promoting inflammation and platelet activation is no known. To investigate this, ...
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  • SARS-CoV-2 productively inf... SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients
    Pontelli, Marjorie C; Castro, Ítalo A; Martins, Ronaldo B ... Journal of molecular cell biology, 08/2022, Volume: 14, Issue: 4
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    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both signature and ...
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  • Effects of Different Media ... Effects of Different Media on Human T Regulatory Cells Phenotype
    GŁaczynska, Magdalena; Machcinska, Maja; Donskow-Lysoniewska, Katarzyna In vivo (Athens), 01/2021, Volume: 35, Issue: 1
    Journal Article
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    Open access

    Functional and quantitative Treg cell defects have been identified in a variety of autoimmune diseases. Therefore, Tregs are a major pharmaceutical target for these disorders. In the last decades, ...
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30.
  • Defective Inflammatory Path... Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response
    Syed, Shariful A.; Beurel, Eléonore; Loewenstein, David A. ... Neuron (Cambridge, Mass.), 09/2018, Volume: 99, Issue: 5
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    Open access

    Inflammation has been involved in the pathophysiology and treatment response of major depressive disorder (MDD). Plasma cytokine profiles of 171 treatment-naive MDD patients (none of the MDD patients ...
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