Information seeking is becoming an indispensable activity in daily life, especially in the medical cloud. Body Area Network (BAN) is becoming more and more popular with respect to the development and ...popularity of mobile devices. People are starting to back up the medical data to cloud, make data accessible by the doctors from almost anywhere using mobile terminals. In this paper, we present an efficient and secure fine-grained access control scheme which not only achieves authorized users to access the records in cloud storage, but also supports a small set of physicians to write on the records. In order to improve the efficiency, we put forward a novel technique called match-then-decrypt, which is used to perform the decryption test without decryption. Also, the scheme outsources bilinear pairing operations to a gateway without revealing the data content, and thus largely eliminates this overhead for users to a great extent. The performance assessments demonstrate the efficiency of our proposed solution in terms of computation, communication, and storage.
Phosphate (Pi) is involved in numerous metabolic processes and plays a vital role in plant growth. Green plants have evolved intricate molecular bases of Pi signaling to maintain cellular Pi ...homeostasis. Here, we summarize recent advances in the molecular and structural bases of central Pi signaling and discuss pending questions.
Owing to the essential requirement of phosphorus (P) for growth and development, plants tightly control inorganic phosphate (Pi) homeostasis. SPX-PHR regulatory circuit not only control phosphate ...homeostasis responses but also root mycorrhization by arbuscular mycorrhiza (AM) fungi. Besides sensing Pi deficiency, SPX (SYG1/Pho81/XPR1) proteins also control the transcription of P starvation inducible (PSI) genes by blocking the activity of PHR1 (PHOSPHATE STARVATION RESPONSE1) homologs in plants under Pi-sufficient conditions. However, the roles of SPX members in Pi homeostasis and AM fungi colonization remain to be fully recognized in tomato. In this study, we identified 17 SPX-domain containing members in the tomato genome. Transcript profiling revealed the high Pi-specific nature of their activation. Four SlSPX members have also induced in AM colonized roots. Interestingly, we found that SlSPX1 and SlSPX2 are induced by P starvation and AM fungi colonization. Further, SlSPX1 and SlSPX2 exhibited varying degrees of interaction with the PHR homologs in this study. Virus-induced gene silencing-based (VIGS) transcript inhibition of these genes alone or together promoted the accumulation of higher total soluble Pi in tomato seedlings and improved their growth. It also enhanced AM fungi colonization in the roots of SlSPX1 and SlSPX2 silenced seedlings. Overall, the present study provides evidence in support of SlSPX members being good candidates for improving AM fungi colonization potential in tomato.
•Solanum lycopersicum (tomato) genome encodes 17 SPX members.•Transient silencing of SlSPX1 and SlSPX2 activates phosphate transport genes and enhance Pi uptake.•Silencing of SlSPX1 and SlSPX2 enhanced mycorrhization in tomato roots.•SlSPXs silencing caused stronger induction of mycorrhizal responsive genes in tomato seedlings.
Unique wellbeing record (PHR)1 will be kept up in the bound together server should keep up the patients near home and PHR administra-tions would outsourced should outcast pro co-ops. Those essential ...concerns may be around examination information. Those tolerant records ought to make if those patients Might truly control those advertising kept up with helter-skelter2 security which is more security. The securi-ty plans are used to protect that particular information from general population get. Tolerant information could make accessed Eventually Tom's perusing A large number distinctive individuals. Each power will be doled out with right reasonably for a specific situated of qualities. The entry control and protection management is an intricate assignment in the tolerant wellbeing record oversaw economy methodology. Conveyed registering may be a casual statement used to depict a combination about Different sorts about registering thoughts that incorpo-rate endless that would chortle through a continuous correspondence a. It may be an identical word to passed on preparing over an arrange-ment and methods those abilities will run a system around a number chortled Pcs meanwhile majority of the data proprietors invigorate those singular data under outcast cloud server ranches. Those novel patient-driven framework Also a suited from claiming data get will instruments will control PHR1 set far over semi-put stock Previously, servers. On finish fine-grained What's more versant majority of the data get will control to PHRs, we utilize quality built encryption (ABE) methodologies on scramble each patient's PHR1 record. Different data proprietors3 camwood get should comparable data values. Those recommended arrangement Might a chance to be arrived at out to pro-gressive quality built encryption (HABE) for get to control part.
Phosphorus (P) deficiency stress in combination with biotic stress(es) severely impacts crop yield. Plant responses to P deficiency overlapping with that of other stresses exhibit a high degree of ...complexity involving different signaling pathways. On the one hand, plants engage with rhizosphere microbiome/arbuscular mycorrhizal fungi for improved phosphate (Pi) acquisition and plant stress response upon Pi deficiency; on the other hand, this association is gets disturbed under Pi sufficiency. This nutrient-dependent response is highly regulated by the phosphate starvation response (PSR) mediated by the master regulator, PHR1, and its homolog, PHL. It is interesting to note that Pi status (deficiency/sufficiency) has a varying response (positive/negative) to different biotic encounters (beneficial microbes/opportunistic pathogens/insect herbivory) through a coupled PSR-PHR1 immune system. This also involves crosstalk among multiple players including transcription factors, defense hormones, miRNAs, and Pi transporters, among others influencing the plant-biotic-phosphate interactions. We provide a comprehensive view of these key players involved in maintaining a delicate balance between Pi homeostasis and plant immunity. Finally, we propose strategies to utilize this information to improve crop resilience to Pi deficiency in combination with biotic stresses.
The fungal cell wall is an ideal target for the design of antifungal drugs. In this study we used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide ...(HCOS), to test its effect against pathogenic Candida strains. Results showed that HCOS was successfully incorporated into the dynamic cell wall organization process and exhibited an apparent antifungal activity against both plankton and mature fungal biofilm, by impairing the cell wall integrity. Unexpectedly, mechanistic studies suggested that HCOS exerts its activity by interfering with family members of PHR β-(1,3)-glucanosyl transferases and affecting the connection and assembly of cell wall polysaccharides. Furthermore, HCOS showed great synergistic activity with different fungicides against Candida cells, especially those in biofilm. These findings indicated HCOS has a great potential as an antifungal drug or drug synergist and proposed a novel antifungal strategy with structure-specific oligosaccharides mimicking cell wall polysaccharide fragments.
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To review and present the relationship and need for integrating EMR, EHR and PHR data, by highlighting its use and value challenges and threats.
Critical overview of the literature.
Electronic ...Medical Records (EMR) and Electronic Health Records (EHR) are used by physicians to improve quality of care and contain costs. Whereas EMR is usually considered an internal organizational system, the EHR is defined as an inter-organizational system. Recently, a computerized platform for patient-centered medical care known as Personal health records (PHR) was introduced, as an enabler for self-management of medical records. PHRs are online systems used by patients. Their transparency of information should lead to better informed and engaged patients.
PHR, EMR and EHR can reside on different platforms under various technologies and standards. Although EMR contains local information and provides fast and accurate delivery, the major advantage of EHR in medical practice is the availability of cross-provider medical information. Patient-centered health initiatives such as PHR enable the integration of the prime information components in the EMR and the EHR systems.
This integration of medical information combines demographic, lifestyle and behavioral data with health records, thus providing a comprehensive view that coincides with the definition of patient-centered medical care. It can lead to a dramatic amelioration in personalized care as well as public health decision-making, resulting in improved health and wellness, but also poses serious challenges and threats to security and privacy.
•EMR & EHR are used by physicians to improve the quality of care.•PHR, EMR & EHR reside different platforms under various technologies and standards.•Major advantage of EHR is the availability of cross-provider medical information.•PHR enables integration of main information components in the EMR & EHR systems.•Medical information integration leads to a dramatic change in personalized care.
As an essential nutrient element, phosphorus (P) plays an important role in plant growth and development. Low P availability is a limiting factor for crop production, especially for legume crops ...(e.g. soybean), which require additional P to sustain nitrogen fixation through symbiotic associations with rhizobia. Although PHOSPHATE STARVATION RESPONSE 1 (PHR1) or PHR1-like is considered as a central regulator of phosphate (Pi) homeostasis in several plant species, it remains undefined in soybean. In this study, 35 GmPHR members were cloned from the soybean genome and expression patterns in soybean were assayed under nitrogen (N) and P deficiency conditions. GmPHR25, which is up-regulated in response to Pi starvation, was then overexpressed in soybean hairy roots in vitro and in vivo to investigate its functions. The results showed that overexpressing GmPHR25 increased Pi concentration in transgenic soybean hairy roots under normal conditions, accompanied with a significant decrease in hairy root growth. Furthermore, transcripts of 11 out of 14 high-affinity Pi transporter (GmPT) members as well as five other Pi starvation-responsive genes were significantly increased in soybean hairy roots with GmPHR25 overexpression. Taken together, this study suggests that GmPHR25 is a vital regulator in the P signaling network, and controls Pi homeostasis in soybean.
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