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  • Diagnostic Criteria for Par... Diagnostic Criteria for Parkinson's Disease: From James Parkinson to the Concept of Prodromal Disease
    Marsili, Luca; Rizzo, Giovanni; Colosimo, Carlo Frontiers in neurology, 03/2018, Volume: 9
    Journal Article
    Peer reviewed
    Open access

    The diagnosis of Parkinson's disease (PD) is based on clinical features and differently to the common opinion that detecting this condition is easy, seminal clinicopathological studies have shown ...
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  • Gut Microbiota Regulate Mot... Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
    Sampson, Timothy R.; Debelius, Justine W.; Thron, Taren ... Cell, 12/2016, Volume: 167, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    The intestinal microbiota influence neurodevelopment, modulate behavior, and contribute to neurological disorders. However, a functional link between gut bacteria and neurodegenerative diseases ...
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  • Non-motor features of Parki... Non-motor features of Parkinson disease
    Schapira, Anthony H V; Chaudhuri, K Ray; Jenner, Peter Nature reviews. Neuroscience, 07/2017, Volume: 18, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for several years, by non-motor symptoms that include hyposmia, sleep disorders, depression and constipation. These ...
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  • Altered gut microbiota and ... Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson's disease
    Lin, Chin-Hsien; Chen, Chieh-Chang; Chiang, Han-Lin ... Journal of neuroinflammation, 06/2019, Volume: 16, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Emerging evidence suggests that gut microbiome composition alterations affect neurodegeneration through neuroinflammation in the pathogenesis of Parkinson's disease (PD). Here, we evaluate gut ...
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  • Parkinson’s disease from th... Parkinson’s disease from the gut
    Liddle, Rodger A. Brain research, 08/2018, Volume: 1693, Issue: Pt B
    Journal Article
    Peer reviewed
    Open access

    A path for α-synuclein from the gut to the nervous system. Enteroendocrine cells (EECs) express α-synuclein and connect to α-synuclein-containing enteric nerves. This circuit provides a possible ...
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  • Parkinson disease and the gut: new insights into pathogenesis and clinical relevance
    Travagli, R Alberto; Browning, Kirsteen N; Camilleri, Michael Nature reviews. Gastroenterology & hepatology, 11/2020, Volume: 17, Issue: 11
    Journal Article
    Peer reviewed

    The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe prodromal, ...
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  • Human iPS cell-derived dopa... Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model
    Kikuchi, Tetsuhiro; Morizane, Asuka; Doi, Daisuke ... Nature (London), 08/2017, Volume: 548, Issue: 7669
    Journal Article
    Peer reviewed

    Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate. However, ...
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  • Positive effect of an elect... Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease
    Bordoni, Laura; Gabbianelli, Rosita; Fedeli, Donatella ... PloS one, 10/2019, Volume: 14, Issue: 10
    Journal Article
    Peer reviewed
    Open access

    There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson's disease (PD). In previous studies we ...
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  • Inflammation in Parkinson's... Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications
    Pajares, Marta; I Rojo, Ana; Manda, Gina ... Cells (Basel, Switzerland), 07/2020, Volume: 9, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra . Although the molecular bases for ...
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  • Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
    Bryois, Julien; Skene, Nathan G; Hansen, Thomas Folkmann ... Nature genetics, 05/2020, Volume: 52, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate ...
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