Overviews the development of biosensors for biomedical applications as well as in the pharmaceutical industry and for food quality control. Source: National Library of New Zealand Te Puna Matauranga ...o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence.
Rapid detection of foodborne pathogens is crucial for protecting food safety and minimizing economic losses. Optical biosensors recognize and quantify pathogenic bacteria through various optical ...signals, and have shown their advantages of fast response, high sensitivity and easy integration. This review described the basic principles of optical biosensors and discussed the essential considerations in sample collection, pathogen isolation and pathogen detection on the applications of optical biosensors for foodborne pathogen detection. Besides, recent advances of the optical biosensors including SPR biosensors, interference biosensors, SERS biosensors, fluorescence biosensors, chemiluminescence biosensors, and colorimetry biosensors reported in the past three years were reviewed. More importantly, the state-of-the-art research and development trends of optical biosensors for the detection of foodborne pathogens were summarized. This review might provide a comprehensive reference for the development of optical biosensors to detect foodborne pathogens.
•Studies on optical biosensors for detection of foodborne pathogens in recent years are reviewed.•Considerations on applications of optical biosensors for detection of foodborne pathogens are discussed.•Trends of optical biosensors for detection of foodborne pathogens are summarized.
The lack of specific, low-cost, rapid, sensitive, and easy detection of biomolecules has resulted in the development of biosensor technology. Innovations in biosensor technology have enabled many ...biosensors to be commercialized and have enabled biomolecules to be detected onsite. Moreover, the emerging technologies of lab-on-a-chip microdevices and nanosensors offer opportunities for the development of new biosensors with much better performance. Biosensors were first introduced into the laboratory by Clark and Lyons. They developed the first glucose biosensor for laboratory conditions. Then in 1973, a glucose biosensor was commercialized by Yellow Springs Instruments. The commercial biosensors have small size and simple construction and they are ideal for point-of-care biosensing. In addition to glucose, a wide variety of metabolites such as lactate, cholesterol, and creatinine can be detected by using commercial biosensors. Like the glucose biosensors (tests) other commercial tests such as for pregnancy (hCG), Escherichia coli O157, influenza A and B viruses, Helicobacter pylori, human immunodeficiency virus, tuberculosis, and malaria have achieved success. Apart from their use in clinical analysis, commercial tests are also used in environmental (such as biochemical oxygen demand, nitrate, pesticide), food (such as glutamate, glutamine, sucrose, lactose, alcohol, ascorbic acid), and biothreat/biowarfare (Bacillus anthracis, Salmonella, Botulinum toxin) analysis. In this review, commercial biosensors in clinical, environmental, food, and biowarfare analysis are summarized and the commercial biosensors are compared in terms of their important characteristics. This is the first review in which all the commercially available tests are compiled together.
A simple and enzyme-free strip biosensor for the amplified detection of Pb super(2+) has been constructed based on a catalytic DNA circuit. This assay is ultrasensitive, enabling the visual detection ...of Pb super(2+) concentrations as low as 10 pM without instrumentation.
Research sciences and medical societies have recently shifted into using cost-effective biosensors to test food & water contaminants, control human biologic processes, assess precise health ...diagnosis, and more. Researchers and medical practitioners need safe and cheaper means of performing their research, ensuring public safety, and delivering customised health options to patients. One such solution can be easily carried out by using biosensors. In the new medical field, biomedical studies of diagnosis are of growing significance. Biosensors' applications are for screening infectious to early detection, chronic disease treatment, health management, and well-being surveillance. Improved biosensors technology qualities allow the ability to detect disease and track the body's response to care. Sensor technology is integral to numerous, low-cost, and improved-form factors feasible in modern medical devices. Biosensors have good potential, as it is easy, scalable and effective in manufacturing processes. This paper discusses biosensors and their significant benefits in the medical field. Distinctive capabilities of biosensors in healthcare services and for cardiovascular disease are provided and shown diagrammatically. The paper also discusses various diagnostic biosensors for cardiovascular diseases and provides novel aspects of biosensors for clinical and allied services. Thereby paper provides significant advancements in biosensors in the medical field. Finally, fourteen major applications of biosensors in the medical field are identified and discussed. Biosensors' intelligent wearable properties now allow older people to control their health with lesser interference, and it directly exchanges their medical-related information with healthcare providers, thereby reducing hospital visits. Thus, biosensors have countless prospects for consumer and commercial uses in wellness, fitness, athletics, etc. Linked biomedical devices, apps, firmware, and sophisticated algorithms will do a lot, including allowing major new medical therapies and informing users about health reform, providing solutions and advice informed by real-time evidence.
In an interview, Professor Paul Berger from Ohio State University in the US talks about the research behind his group's Letter: "Towards in vivo biosensors for low-cost protein sensing." Over the ...years he has studied active semiconductor devices, often exploring ways to use new materials or modify a material's properties to create enhanced device performance. His work has studied every major semiconductor device, including HBT, MODFET, tunnel diodes, LEDs, laser diodes, solar cells, photodetectors, and optical modulators. Open discussions with a colleague in the biomedical engineering discipline piqued his curiosity, which excited him to their specific need and the opportunity he could exploit by judicious engineering. They are also exploring plasmonically assisted plastic solar cells for energy harvesting.
Novel spherical PdatCys-C sub(60) nanoparticles were synthesized using an in situspontaneous reduction process without any other reducing agent. A nonenzymatic electrochemical biosensor was developed ...for the detection of glucose based on the spherical nanoparticles film.
Early diagnosis and ultrahigh sample throughput screening are the need of the hour to control the geological spread of the COVID-19 pandemic. Traditional laboratory tests such as enzyme-linked ...immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) and computed tomography are implemented for the detection of COVID-19. However, they are limited by the laborious sample collection and processing procedures, longer wait time for test results and skilled technicians to operate sophisticated facilities. In this context, the point of care (PoC) diagnostic platform has proven to be the prospective approach in addressing the abovementioned challenges. This review emphasizes the mechanism of viral infection spread detailing the host-virus interaction, pathophysiology, and the recent advances in the development of affordable PoC diagnostic platforms for rapid and accurate diagnosis of COVID-19. First, the well-established optical and electrochemical biosensors are discussed. Subsequently, the recent advances in the development of PoC biosensors, including lateral flow immunoassays and other emerging techniques, are highlighted. Finally, a focus on integrating nanotechnology with wearables and smartphones to develop smart nanobiosensors is outlined, which could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care.
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•Emphasizing the huge demand for affordable point of care diagnostic tools to control the global COVID-19 pandemic.•Highlighting the recent advances in the development of PoC based optical and electrochemical biosensors.•Reviewed the application of wearables and smart nanobiosensors for real time monitoring of COVID-19.
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