Between 1968 and 1980, fears about family deterioration and national decline were ubiquitous in American political culture. InNo Direction Home, Natasha Zaretsky shows that these perceptions of ...decline profoundly shaped one another.Throughout the 1970s, anxieties about the future of the nuclear family collided with anxieties about the direction of the United States in the wake of military defeat in Vietnam and in the midst of economic recession, Zaretsky explains. By exploring such themes as the controversy surrounding prisoners of war in Southeast Asia, the OPEC oil embargo of 1973-74, and debates about cultural narcissism, Zaretsky reveals that the 1970s marked a significant turning point in the history of American nationalism. After Vietnam, a wounded national identity--rooted in a collective sense of injury and fueled by images of family peril--exploded to the surface and helped set the stage for the Reagan Revolution. With an innovative analysis that integrates cultural, intellectual, and political history,No Direction Homeexplores the fears that not only shaped an earlier era but also have reverberated into our own time.
Who are white working class people? What do they believe? What has driven them to break so sharply with the world's trajectory toward a more borderless, interconnected meritocracy? The White Working ...Class: What Everyone Needs to Know? presents the context for understanding the political ideologies, actions, and behavior of this complicated constituency. Providing an accessible introduction to the white working class, this book argues that they must be understood if the world is to address and respond to the social and political phenomena they are driving.
This book puts middle Australia under the microscope, examining how quality of life is faring in the face of change and uncertainty. 400 Australians from around the country shared their experiences ...of work, family, and community for this book, creating a striking picture of Australian society into a new millennium. This lived experience is set against hard data so that we can truly understand the impact - good and bad - of economic restructuring on the broad Australian middle class. Meticulously researched, it mounts a moral and intellectual counter-argument to economic reform. A sequel to the best-selling Economic Rationalism in Canberra, Michael Pusey's book will be equally important.
Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV. The situation is getting ...worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS‐COV‐2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex‐(MHC) I and 3 MHC‐II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll‐like receptor‐5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
Highlights
The potential epitopes of coronavirus (SARS‐CoV‐2) are identified.
The docking complex of the construct vaccine and TLR5 is described.
Peptide‐based vaccine developed and in silico validation is provided.
Common epitopes of coronavirus (SARS‐CoV‐2) against B‐cells and T‐cells are listed.
One of the most significant events in European politics the past two decades is the emergence of radical right-wing parties, mobilizing against immigration and multiethnic societies. Such parties ...have established themselves in a large number of countries, often with voter shares exceeding ten and sometimes even twenty percent. Many of these parties exert a real influence on the policy within respective country.
The emergence of the recent wave of radical right-wing party politics has generated a large and growing literature, spanning a variety of dimensions-such as ideology, voting, and policy impact. This volume will cover all these dimensions, but it will in particular focus on two questions: why is it that the working class tends to be especially attracted by the radical right-wing parties? And what does the radical right-wing parties growing electoral successes mean for Social Democracy and the traditional left in Europe, which are meeting growing competition from the radical right over working class voters? Bringing together the leading scholars within this field, this book makes a unique contribution by focusing on the relationship between class politics and the radical right.
Lymphocyte-activation gene 3 (LAG-3) is an immune inhibitory receptor, with major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains controversial whether MHC-II ...is solely responsible for the inhibitory function of LAG-3. Here, we demonstrate that fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy. Our findings reveal an immune evasion mechanism and have implications for the design of cancer immunotherapy.
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•FGL1 is a major ligand of LAG-3 that mediates T cell suppression•FGL1 is normally released by the liver in low levels but by cancer in high levels•Blockade of the FGL1-LAG-3 interaction potentiates anti-tumor immunity
FGL1 is identified as a major ligand for the inhibitory receptor LAG-3, and its blockade can potentiate anti-tumor T cell responses.
Unequal City Hamnett, Chris
2003, 20040601, 2004-06-01, 20020101, 20030101
eBook
Unequal City examines some of the dramatic economic and social changes that have taken place in London over the last forty years. It describes how London's changing industrial structure, particularly ...the shift from an industrial to a services-based city, and the associated changes in occupational class structure and in the structure of earnings and incomes, have worked through to the housing market and the gentrification of large parts of inner London. Unequal City relates to the literature on global cities. The book has a wide sweep and summarises a wide range of literature on occupational and industrial change, earnings and incomes and the housing market and gentrification. It provides a wealth of original data, figures, maps and tables and will be a valuable reference for anyone interested in the changes that have reshaped the social structure of London in recent decades.
This is an innovative study of middle-class behaviour and property relations in English towns in Georgian and Victorian Britain. Through the lens of wills, family papers, property deeds, account ...books and letters, the author offers a reading of the ways in which middle-class families survived and surmounted the economic difficulties of early industrial society. He argues that these were essentially 'networked' families created and affirmed by a 'gift' network of material goods, finance, services and support, with property very much at the centre of middle-class survival strategies. His approach combines microhistorical studies of individual families with a broader analysis of the national and even international networks within which these families operated. The result is a significant contribution to the history, and to debates about the place of structural and cultural analysis in historical understanding.
This book maps how working class life was transformed in England in the middle years of the twentieth century. National trends in employment, welfare and living standards are illuminated via a focus ...on Brighton, providing valuable new perspectives of class and community formation. Based on fresh archival research, life histories and contemporary social surveys, the book historicises important cultural and community studies which moulded popular perceptions of class and social change in the post-war period. It shows how council housing, slum clearance and demographic trends impacted on working-class families and communities. While suburbanisation transformed home life, leisure and patterns of association, there were important continuities in terms of material poverty, social networks and cultural practices. This book will be essential reading for academics and students researching modern and contemporary social and cultural history, sociology, cultural studies and human geography.Academics and students researching modern and contemporary social and cultural history, sociology, cultural studies and human geography
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