Coronavirus disease 2019 has stretched the ability of many institutions to supply needed personal protective equipment, especially N95 respirators. N95 decontamination and re-use programmes provide ...one potential solution to this problem. Unfortunately, a comprehensive evaluation of the effects of decontamination on the fit of various N95 models using a quantitative fit test (QNFT) approach is lacking.
To investigate the effects of up to eight rounds of vaporized hydrogen peroxide (VHP) decontamination on the fit of N95 respirators currently in use in a hospital setting, and to examine if N95 respirators worn by one user can adapt to the face shape of a second user with no compromise to fit following VHP decontamination.
The PortaCount Pro+ Respirator Fit Tester Model 8038 was used to quantitatively define functional integrity, measured by fit, of N95 respirators following decontamination with VHP.
There was an observable downward trend in the functional integrity of Halyard Fluidshield 46727 N95 respirators throughout eight cycles of decontamination with VHP. Functional integrity of 3M 1870 N95 respirators was reduced significantly after the respirator was worn, decontaminated with VHP, and then quantitatively fit tested on a second user. Furthermore, inconsistencies between qualitative fit test and QNFT results were uncovered that may have strong implications on the fit testing method used by institutions.
The data revealed variability in the functional integrity of different N95 models after VHP decontamination, and exposed potential limitations of N95 decontamination and re-use programmes.
The treatment of wastewater has become increasingly challenging as a result of its growing complexity. To achieve synergistic removal of coexisting pollutants in wastewater, one promising approach ...involves the integration of electric fields. We conducted a comprehensive literature review to explore the potential of integrating electric fields and developing efficient electro-intensified simultaneous decontamination systems for wastewater containing coexisting pollutants. The review focused on comprehending the applications and mechanisms of these systems, with a particular emphasis on the deliberate utilization of positive and negative charges. After analyzing the advantages, disadvantages, and application efficacy of these systems, we observed electro-intensified systems exhibit flexible potential through their rational combination, allowing for an expanded range of applications in addressing simultaneous decontamination challenges. Unlike the reviews focusing on single elimination, this work aims to provide guidance in addressing the environmental problems resulting from the coexistence of hazardous contaminants.
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•Electro-intensified systems for simultaneous decontamination were summarized.•The applications and underlying mechanisms were analyzed.•The integration of electro-intensified systems was discussed in detail.•This review offers guidance for the challenges posed by coexisting hazards.
Selective decontamination of the digestive tract (SDD) is an infection prevention measure for intensive care unit (ICU) patients that was proposed more than 30 years ago, and that is currently ...considered standard of care in the Netherlands, but only used sporadically in ICUs in other countries. In this narrative review, we first describe the rationale of the individual components of SDD and then review the evidence base for patient-centered outcomes, where we distinguish ICUs with low prevalence of antibiotic resistance from ICUs with moderate–high prevalence of resistance. In settings with low prevalence of antibiotic resistance, SDD has been associated with improved patient outcome in three cluster-randomized studies. These benefits were not confirmed in a large international cluster-randomized study in settings with moderate-to-high prevalence of antibiotic resistance. There is no evidence that SDD increases antibiotic resistance. We end with future directions for research.
•A method based on dose rate was proposed to estimate the expected contaminated people at each assemble point in nuclear accident scenarios, which is more rigorous compared with the other methods ...using average wind frequency and assembly point orientation.•Combined with public contaminated proportion, population structure and waiting psychology, a public decontamination model based on queuing theory and system dynamics method was proposed for offsite nuclear emergency to quantify the decontamination process and estimate overall time.•A configuration plan for adding devices was provided to meet the time requirement and control the number of waiting queues within the specified threshold efficiently.•The proposed method can help nuclear emergency decision-makers display the decontamination process, estimate the overall time and optimize site configuration plan.
Decontamination is an important means to reduce the personnel radioactive contamination under sever nuclear accidents. Public decontamination time estimation with the process simulation is helpful for emergency organizations to improve efficiency. To date, most studies focus on improving personal decontamination technology and decontamination strategies, while research on the overall decontamination process and time estimating is limited. Due to the complex population structure, the unknown contaminated proportion and the complicated psychological emotions, it is hard to quantify the decontamination process and calculate the decontamination time with numerous procedures and diverse facility configurations. Combined with public contaminated proportion, crowd structure and waiting psychology, a public decontamination model based on queuing theory and system dynamics method is established for offsite nuclear emergency to simulate the decontamination process and give an estimate of decontamination time. A hypothetical nuclear leakage accident of Changjiang Nuclear Power Plant in Hainan, China is conducted to simulate the established model. The results show the working status of different facilities at different stages and the changes in waiting queues at different times, which can effectively calculate the duration time of each link and the overall public decontamination progress. A plan for adding devices is provided to meet the decontamination time requirements and control the number of waiting queues within the specified threshold efficiently. The method proposed in this paper could help nuclear emergency decision-makers estimate the public decontamination time, optimize site configuration plans, give guidance on public decontamination procedures and prepare for the subsequent nuclear emergency evacuation.
By definition, the nonthermal plasma (NTP) is partially ionized gas where the energy is stored mostly in the free electrons and the overall temperature remains low. NTP is widely used for many years ...in various applications such as low-temperature plasma chemistry, removal of gaseous pollutants, in gas-discharge lamps or surface modification. However, during the last ten years, NTP usage expanded to new biological areas of application like plasma microorganisms' inactivation, ready-to-eat food preparation, biofilm degradation or in healthcare, where it seems to be important for the treatment of cancer cells and in the initiation of apoptosis, prion inactivation, prevention of nosocomial infections or in the therapy of infected wounds. These areas are presented and documented in this paper as a review of representative publications.
PURPOSE OF REVIEWThis article reviews ‘no touch’ methods for disinfection of the contaminated surface environment of hospitalized patients’ rooms. The focus is on studies that assessed the ...effectiveness of ultraviolet (UV) light devices, hydrogen peroxide systems, and self-disinfecting surfaces to reduce healthcare-associated infections (HAIs).
RECENT FINDINGSThe contaminated surface environment in hospitals plays an important role in the transmission of several key nosocomial pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp., Clostridium difficile, Acinetobacter spp., and norovirus. Multiple clinical trials have now demonstrated the effectiveness of UV light devices and hydrogen peroxide systems to reduce HAIs. A limited number of studies have suggested that ‘self-disinfecting’ surfaces may also decrease HAIs.
SUMMARYMany studies have demonstrated that terminal cleaning and disinfection with germicides is often inadequate and leaves environmental surfaces contaminated with important nosocomial pathogens. ‘No touch’ methods of room decontamination (i.e., UV devices and hydrogen peroxide systems) have been demonstrated to reduce key nosocomial pathogens on inoculated test surfaces and on environmental surfaces in actual patient rooms. Further UV devices and hydrogen peroxide systems have been demonstrated to reduce HAI. A validated ‘no touch’ device or system should be used for terminal room disinfection following discharge of patients on contact precautions. The use of a ‘self-disinfecting’ surface to reduce HAI has not been convincingly demonstrated.
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•Green decontamination tool was created to eliminate predators cidal to H. pluvialis.•CBDS was conducted at mild alkalinity and low CaCl2 for non-calcifying H. pluvialis.•CBDS showed ...an efficient removal of algicidal bacteria and fungi during cultivation.•Astaxanthin production using CBDS was significantly enhanced in H. pluvialis.•Large-scale outdoor astaxanthin production in H. pluvialis was improved by CBDS.
Currently, there is a lack of an efficient, environmentally-benign and sustainable industrial decontamination strategy to steadily achieve improved astaxanthin production from Haematococcus pluvialis under large-scale outdoor conditions. Here, this study demonstrates for the first time that a CaCO3 biomineralization-based decontamination strategy (CBDS) is highly efficient in selectively eliminating algicidal microorganisms, such as bacteria and fungi, during large-scale H. pluvialis cultivation under autotrophic and mixotrophic conditions, thereby augmenting the astaxanthin productivity. Under outdoor AT and MT conditions, the average astaxanthin productivity of H. pluvialis using CBDS in a closed photobioreactor system was substantially increased by 14.85- (1.19 mg L−1 d−1) and 13.65-fold (2.43 mg L−1 d−1), respectively, compared to the contaminated H. pluvialis cultures. Given the exponentially increasing demand of astaxanthin, a natural anti-viral, anti-inflammatory, and antioxidant drug, CBDS will be a technology of interest in H. pluvialis-based commercial astaxanthin production which has been hindered by the serious biological contaminations.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has devastated global public health systems and economies, with over 52 million people infected, millions of jobs and ...businesses lost, and more than 1 million deaths recorded to date. Contact with surfaces contaminated with droplets generated by infected persons through exhaling, talking, coughing and sneezing is a major driver of SARS-CoV-2 transmission, with the virus being able to survive on surfaces for extended periods of time. To interrupt these chains of transmission, there is an urgent need for devices that can be deployed to inactivate the virus on both recently and existing contaminated surfaces. Here, we describe the inactivation of SARS-CoV-2 in both wet and dry format using radiation generated by a commercially available Signify ultraviolet (UV)-C light source at 254 nm. We show that for contaminated surfaces, only seconds of exposure is required for complete inactivation, allowing for easy implementation in decontamination workflows.
•Both DDGel and RSDL significantly removed CEES from skin.•DDGel showed higher decontamination efficiency than RSDL.•DDGel back-extracted chemicals from SC and reduced penetrating deeper skin layers.
...This study compared the efficiency for in vitro human skin decontamination using DDGel and RSDL. Experiments were performed using in vitro human skin models, in which skin was mounted onto Flow-Through diffusion cells. The mass of 14-C CEES removed from skin surface after decontamination was quantitated by measuring radioactivity with a liquid scintillation spectrometer. Both decontaminants removed more than 82% of CEES from skin. DDGel skin decontamination significantly reduced toxicant amount when compared to RSDL. Mean CEES remaining in stratum corneum (SC), viable epidermis, dermis, and systemic absorption of DDGel and RSDL were, 0.12 and 0.55% (P < 0.01), 0.31 and 0.95% (p < 0.01), 1.08 and 2.92% (p < 0.05), 3.13 and 6.34% (p < 0.05), respectively. DDGel showed higher decontamination efficiency (twice decontamination efficacy factor, DEF) than RSDL and efficiently removed chemicals from the skin surface, importantly back-extracted from the SC, and significantly reduced both chemical penetration into skin and systemic absorption. Thus, DDGel can offer a potential as a next generation skin decontamination platform technology for military and civilian applications.
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