Designing for dissemination and sustainability (D4DS) refers to principles and methods for enhancing the fit between a health program, policy, or practice and the context in which it is intended to ...be adopted. In this article we first summarize the historical context of D4DS and justify the need to shift traditional health research and dissemination practices. We present a diverse literature according to a D4DS organizing schema and describe a variety of dissemination products, design processes and outcomes, and approaches to messaging, packaging, and distribution. D4DS design processes include stakeholder engagement, participatory codesign, and context and situation analysis, and leverage methods and frameworks from dissemination and implementation science, marketing and business, communications and visualarts, and systems science. Finally, we present eight recommendations to adopt a D4DS paradigm, reflecting shifts in ways of thinking, skills and approaches, and infrastructure and systems for training and evaluation.
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Solid-state Li-ion batteries (SSLBs) are promising next-generation energy storage devices with high energy density and enhanced safety. The solid-state electrolyte (SSE) is a key ...component for delivering the desired electrochemical performance characteristics. This article provides a brief review of the discovery, synthesis, structure, ion-conduction mechanism, and application of LGPS-type and garnet-type Li ion conductors as two representative SSEs, aiming to extract principles for the future design and discovery of favourable solid-state Li-ion electrolytes for SSLBs. Recent advances in strategies to address the SSLB challenges are also discussed. Finally, a perspective on the future research directions of SSLBs is provided.
Abstract Introduction. According to DSTU 8814: 2018 “Road bridges. Terms and Definitions” transport facility is a structure to ensure the proper functioning of the road in difficult geological and ...hydrological conditions, as well as in the case of crossing the road obstacles: watercourses, highways, railways, etc. One of the indicators of safe operation and normal functioning of roads and transport facilities located on them is the dimension of the roadway - the width of the bridge deck, which is intended for the location of the roadway and safety lanes. Problem statement. The designing of transport facilities is a creative, but at the same time responsible process, which in turn is due to certain regulatory restrictions. One of the important designing criteria is the dimension of the roadway. Since the structure is located on the road, the width of the road should be harmonized with it and not create inconvenience to road users by decreasing of traffic speeds or inconveniences for low-mobility groups on sidewalks, the formation of "tunnel effect", etc. Actually, according to the Analytical Expert Bridge Management System (AESUM) in Ukraine, about 30% of structures on public roads have a dimension that does not meet the requirements of regulations on the width of the roadway. And transport facilities with oversized dimensions are more than 60% (9896 bridges and overpasses). The need to consider this topic is to harmonize the rules for the designing of bridges and roads, improving traffic safety and as a consequence increasing the financial efficiency of transportation. Purpose. The purpose of study is to draw the attention of structures owners, customers and design organizations to the importance of harmonious coexistence of roads and buildings located on them. Also, to draw the attention of developers of regulatory documents to the fact that the narrow dimensions of transport facilities can cause difficulties during the repairing works with partial blockage of traffic. Results. “DerzhdorNDI” SE scientists performed an analysis of regulatory documents on the determination of the dimensions of transport facilities for more than 70 years. Conclusions. According to the results of analysis of regulations on the determination of transport facilities dimensions, an example was presented, in accordance with current regulations, when a collision occurs after repairing works, namely the need to install “Road Narrowing” signs. Also the emphasis had been placed on further harmonization of regulations on the designing of roads and transport facilities. Keywords: transport facilities, roads, dimension, road
PIM-1 kinase belongs to the Ser/Thr kinases family, an attractive therapeutic target for prostate cancer. Here, we screened about 100 natural substances to find potential PIM-1 inhibitors. Two ...natural compounds, Naringenin and Quercetin, were finally selected based on their PIM-1 inhibitory potential and binding affinities. The docking score of Naringenin and Quercetin with PIM-1 is −8.4 and − 8.1 kcal/mol, respectively. Fluorescence binding studies revealed a strong affinity (Ka values, 3.1 × 104 M−1 and 4.6 × 107 M−1 for Naringenin and Quercetin, respectively) with excellent IC50 values for Naringenin and Quercetin (28.6 μM and 34.9 μM, respectively). Both compounds inhibited the growth of prostate cancer cells (LNCaP) in a dose-dependent manner, with the IC50 value of Naringenin at 17.5 μM and Quercetin at 8.88 μM. To obtain deeper insights into the PIM-1 inhibitory effect of Naringenin and Quercetin, we performed extensive molecular dynamics simulation studies, which provided insights into the binding mechanisms of PIM-1 inhibitors. Finally, Naringenin and Quercetin were suggested to serve as potent PIM-1 inhibitors, offering targeted treatments of prostate cancer. In addition, our findings may help to design novel Naringenin and Quercetin derivatives that could be effective in therapeutic targeting of prostate cancer.
•PIM-1 is an attractive drug target for prostate cancer therapy.•We have discovered Naringenin and Quercetin as potent PIM-1 kinase inhibitors.•Docking and MD simulation studies suggested a strong binding and the formation of stable protein-ligands complexes.•Naringenin and Quercetin significantly inhibit the activity of PIM-1 with excellent IC50 values.•Both compounds show cytotoxic effect on LNCaP cells with admirable IC50 values.
Additive manufacturing technologies can now be used to manufacture metallic parts. This breakthrough in manufacturing technology makes possible the fabrication of new shapes and geometrical features. ...Although the manufacturing feasibility of sample parts with these processes has been the subject of several studies, the breakthrough in manufacturing is yet to be followed by a breakthrough in designing process. In this paper, after reviewing the principle of additive manufacturing of metallic parts, the manufacturing capabilities and constraints of these processes will be examined. A designing methodology will then be suggested and illustrated with the redesign of an example part.
Geographies of resilience Weichselgartner, Juergen; Kelman, Ilan
Progress in human geography,
06/2015, Volume:
39, Issue:
3
Journal Article
Peer reviewed
Open access
In disaster science, policy and practice, the transition of resilience from a descriptive concept to a normative agenda provides challenges and opportunities. This paper argues that both are needed ...to increase resilience. We briefly outline the concept and several recent international resilience-building efforts to elucidate critical questions and less-discussed issues. We highlight the need to move resilience thinking forward by emphasizing structural social-political processes, acknowledging and acting on differences between ecosystems and societies, and looking beyond the quantitative streamlining of resilience into one index. Instead of imposing a technical-reductionist framework, we suggest a starting basis of integrating different knowledge types and experiences to generate scientifically reliable, context-appropriate and socially robust resilience-building activities.
•The synthetic strategies of meso-MOFs have been comprehensively reviewed.•The tactics for generating active sites on meso-MOFs for catalysis are covered.•The role of mesopores of MOFs on ...heterogeneous catalysis is emphasized.•Current challenges and future directions for meso-MOFs-based catalysts are provided.
Mesoporous metal–organic frameworks (meso-MOFs) are emerging as promising functional materials for heterogeneous catalysis due to their high surface area, porosity, readily adjustable structures and tunable functionalities. Their properties and functions are often dictated by the size and shape of pores in their frameworks. Mesopores in MOFs can decline mass transfer and exchange resistance in a confined space, leading to the improvement of their catalytic performances. However, it is challenging to synthesize and apply meso-MOFs for catalysis owing to the requirement of a combination of good chemical stability and large pore size. So far, there have been few efforts to comprehensively discuss these issues. Based on selected recent reports, this review will provide a concise overview in the field of meso-MOFs, associated with their synthetic strategies and intriguing tactics of generating active sites for heterogeneous catalysis.
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