Porast slučajeva muške neplodnosti tijekom posljednja dva desetljeća, vjerojatno i zbog izloženosti okolišnim čimbenicima, izazvao je značajan interes. Izvješća klinika za neplodnost pokazala su da ...kronične bolesti i nasljedni čimbenici ili neke zdravstvene smetnje mogu samo djelomično objasniti trenutačnu incidenciju muške neplodnosti. Životni okoliš i radna okolina mogu imati značajnu ulogu u izlaganju složenim smjesama spojeva s endokrinim djelovanjem (ED), koji su povezani s raznim poremećajima plodnosti. Cilj je ovoga preglednog rada dati uvid u trenutačno znanje o tipovima izloženosti koji mogu biti povezani s muškom neplodnošću. Naše se istraživanje oslanjalo na sustavnu pretragu PubMeda, Scopusa i Web of Sciencea za članke objavljene od siječnja 2000. do rujna 2020. Rezultati su pokazali da je za neke čimbenike dobro dokumentirana povezanost s muškom neplodnošću, što uključuje pušenje, neke fiziološke poremećaje te kronične bolesti poput pretilosti i dijabetesa, koji sami po sebi mogu odražavati životne navike i izloženost okolišu, posebice spojevima s ED-om poput ftalata, bisfenola, pesticida i protupožarnih zaštita. Međutim, broj studija o etiologiji muške neplodnosti još je uvijek premalen u usporedbi s veličinom zahvaćene populacije. Medicina rada tijekom sistematskih pregleda ne prikuplja podatke o muškoj neplodnosti premda su spojevi s ED-om prisutni u mnogim tehnološkim procesima.
The upsurge in male infertility over the last two decades, possibly due to environmental exposure, has raised significant interest, particularly boosted by reports from fertility clinics, which ...showed that chronic diseases and hereditary or other medical conditions might only partially explain current incidence of male infertility. Both environmental and occupational settings may have a significant role in exposure to complex mixtures of endocrine disruptors (ED), which play a major role in fertility disorders. The aim of this review is to give an insight into the current knowledge on exposure settings which may be associated with male infertility. Our study relied on a systematic search of PubMed, Scopus, and Web of Science for articles published between January 2000 and September 2020. It showed that some well documented factors associated with male infertility include smoking, and physiological disturbances or chronic diseases such as obesity and diabetes, which in turn, may also reflect lifestyle choices and environmental exposures, especially to EDs such as phthalates, bisphenols, pesticides, and flame retardants. However, the number of studies on the aetiology of male infertility is still too low in comparison with the size of affected population. Occupational health follow-ups and medical surveillance do not collect any data on male infertility, even though ED chemicals are part of many technological processes.
L’allergie de contact aux conservateurs et agent de vulcanisation de la batterie standard évolue : les modes d’utilisation changent en fonction des marchés et de la législation.
Allergy due to ...preservatives and vulcanisation agents in the standard series changes according to the marketing and the different regulations.
Les perturbateurs endocriniens sont des contaminants ubiquitaires de notre environnement. Leurs effets délétères sur la reproduction sont bien documentés. L’objectif est de décrire l’état de ...connaissance actuel portant sur les issues de la grossesse.
Revue de la littérature réalisée par deux personnes indépendantes dans la base de données Medline et Toxnet. Les polluants étudiés ont été le bisphénol A, les phtalates, les parabens, les retardateurs de flammes bromés et les composés perfluorés indépendamment de leurs voies d’expositions. Seules les études épidémiologiques, en population générale, portant sur l’homme, parues avec un abstract du 1er janvier 2007 au 31 décembre 2011 ont été retenues. La qualité n’a pas été un critère de sélection mais a été prise en compte par la cotation du score de Strobe.
Vingt-cinq études sur 680 ont été inclues. Tous les polluants ont été fortement détectés dans tous les prélèvements biologiques maternels et du nouveau-né. Les principales études ont rapporté des relations entre le bisphénol A, les retardateurs de flammes bromés et les composés perfluorés et un plus faible poids de naissance du nouveau-né. Les effets sur l’âge gestationnel ont été moins documentés et en faveur d’une absence de lien pour ces polluants. Les effets dus aux phtalates étaient plus ambigus. Une seule étude non concluante concernait les parabens.
Compte tenu des biais de méthodologie inhérents aux études sur les perturbateurs endocriniens, il est primordial de multiplier les recherches en santé environnementale. Des mesures de prévention doivent être appliquées en priorité sur les populations vulnérables.
Endocrine disruptors are ubiquitous chemicals contaminants in the environment, wildlife, and humans. Their adverse effects on reproduction are well-documented. There is growing evidence that they can contribute to the current emergence of chronic diseases.
Our aim is to assess the relationships between endocrine disruptors and the neonatal health outcomes.
Two persons have independently reviewed Medline and Toxline databases about the following pollutants: bisphenol A, phthalates, parabens, brominated flame retardants and perfluorinated compounds. Only the human epidemiological studies, in general population with an abstract available, published between 2007 January the 1st and 2011 December the 31st, were analysed. The quality of each study was assessed with the Strobe score.
Twenty-five out of 680 studies were included in the analysis. All pollutants were widely detected in maternal and new borns samples. Most of the studies have shown associations between bisphenol A, brominated flame retardants and perfluorinated compounds and lower birth weight. The effects on gestational age were less documented and have shown no clear connection. Results for phthalates were more ambiguous. Only one non-instructive study was found on parabens.
Due to the inherent methological bias on endocrine disruptors research, further additional studies on environmental health must be investigated. It seems necessary to adopt preventive health measures first for vulnerable population.
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