Maillard reaction in food allergy: Pros and cons Gupta, Rinkesh Kumar; Gupta, Kriti; Sharma, Akanksha ...
Critical reviews in food science and nutrition,
01/2018, Volume:
58, Issue:
2
Journal Article
Peer reviewed
Food allergens have a notable potential to induce various health concerns in susceptible individuals. The majority of allergenic foods are usually subjected to thermal processing prior to their ...consumption. However, during thermal processing and long storage of foods, Maillard reaction (MR) often takes place. The MR is a non-enzymatic glycation reaction between the carbonyl group of reducing sugars and compounds having free amino groups. MR may sometimes be beneficial by damaging epitope of allergens and reducing allergenic potential, while exacerbation in allergic reactions may also occur due to changes in the motifs of epitopes or neoallergen generation. Apart from these modulations, non-enzymatic glycation can also modify the food protein(s) with various type of advance glycation end products (AGEs) such as Nϵ-(carboxymethyl-)lysine (CML), pentosidine, pyrraline, and methylglyoxal-H1 derived from MR. These Maillard products may act as immunogen by inducing the activation and proliferation of various immune cells. Literature is available to understand pathogenesis of glycation in the context of various diseases but there is hardly any review that can provide a thorough insight on the impact of glycation in food allergy. Therefore, present review explores the pathogenesis with special reference to food allergy caused by non-enzymatic glycation as well as AGEs.
All organisms produce specialized organic molecules, ranging from small volatile chemicals to large gene-encoded peptides, that have evolved to provide them with diverse cellular and ecological ...functions. As natural products, they are broadly applied in medicine, agriculture and nutrition. The rapid accumulation of genomic information has revealed that the metabolic capacity of virtually all organisms is vastly underappreciated. Pioneered mainly in bacteria and fungi, genome mining technologies are accelerating metabolite discovery. Recent efforts are now being expanded to all life forms, including protists, plants and animals, and new integrative omics technologies are enabling the increasingly effective mining of this molecular diversity.
HIV-1 candidate vaccines expressing an artificial polyprotein comprising Gag, Pol and Nef (GPN) and a secreted envelope protein (Env) were shown in recent Phase I/II clinical trials to induce high ...levels of polyfunctional T cell responses; however, Env-specific responses clearly exceeded those against Gag. Here, we assess the impact of the GPN immunogen design and variations in the formulation and vaccination regimen of a combined GPN/Env DNA vaccine on the T cell responses against the various HIV proteins. Subtle modifications were introduced into the GPN gene to increase Gag expression, modify the expression ratio of Gag to PolNef and support budding of virus-like particles. I.m. administration of the various DNA constructs into BALB/c mice resulted in an up to 10-fold increase in Gag- and Pol-specific IFNγ(+) CD8(+) T cells compared to GPN. Co-administering Env with Gag or GPN derivatives largely abrogated Gag-specific responses. Alterations in the molar ratio of the DNA vaccines and spatially or temporally separated administration induced more balanced T cell responses. Whereas forced co-expression of Gag and Env from one plasmid induced predominantly Env-specific T cells responses, deletion of the only H-2(d) T cell epitope in Env allowed increased levels of Gag-specific T cells, suggesting competition at an epitope level. Our data demonstrate that the biochemical properties of an artificial polyprotein clearly influence the levels of antigen-specific T cells, and variations in formulation and schedule can overcome competition for the induction of these responses. These results are guiding the design of ongoing pre-clinical and clinical trials.
The majority of foods that are consumed in our developed society have been processed. Processing promotes a non-enzymatic reaction between proteins and sugars, the Maillard reaction (MR). Maillard ...reaction products (MRPs) contribute to the taste, smell and color of many food products, and thus influence consumers' choices. However, in recent years, MRPs have been linked to the increasing prevalence of diet- and inflammation-related non-communicable diseases including food allergy. Although during the last years a better understanding of immunogenicity of MRPs has been achieved, still only little is known about the structural/chemical characteristics predisposing MRPs to interact with antigen presenting cells (APCs). This report provides a comprehensive review of recent studies on the influence of the Maillard reaction on the immunogenicity and allergenicity of food proteins.
•Consumer valuation of local-regional-traditional food products is very high.•Local-regional-traditional foods are more valued than other foods.•Consumer ethnocentrism is related to the effective ...purchase of local-regional-traditional food.•The effects of consumer ethnocentrism can be direct and/or indirect.•The effects of consumer ethnocentrism vary among different product categories.
Previous literature has addressed the concepts of local products, regional products and traditional products as if they were independent concepts. However, in practice, many food products combine all three concepts. The objectives of this paper are as follows: first, to explore the valuation of food products that have local, regional and traditional features through the analysis of specific product categories; second, to study the possible link between the level of consumer ethnocentrism and the valuation and effective purchase of local-regional-traditional food.
The results show that consumers value these products highly and buy them in high proportions. In addition, levels of consumer ethnocentrism are sometimes, but not always, related to the actual purchase of these local-regional-traditional food products. This finding highlights the need to include a product’s category in analyses of the effects of consumer ethnocentrism.
The majority of previous studies examine the consumer’s valuation and intention to buy local or traditional products at a general or abstract level, which does not allow respondents to evaluate a specific food product that they can find in the market and consume. An important contribution of this work is its level of analysis: we analyze specific food product categories in two different geographic environments in Spain.
How do markets evolve? Why are some innovations picked up straightaway whilst others take years to be commercialized? Are there first-mover advantages? Why do we behave with 'irrational exuberance' ...in the early evolution of markets as was the case with the dot.com boom? Paul Geroski is a leading economist who has taught economics to business school students, managers, and executives at the London Business School. In this book he explains in a refreshingly clear style how markets develop. In particular he stresses how the early evolution of markets can significantly shape their later development and structure. His purpose is to show how a good grasp of economics can improve managers' business and investment decisions. Whilst using the development of the Internet as a case in point, Geroski also refers to other sectors and products, for example cars, television, mobile phones, and personal computers. This short book is an ideal introduction for managers, MBA students, and the general reader wanting to understand how markets evolve. Available in OSO: http://www.oxfordscholarship.com/oso/public/content/economicsfinance/0199248893/toc.html
Microorganisms have provided abundant sources of natural products which have been developed as commercial products for human medicine, animal health, and plant crop protection. In the early years of ...natural product discovery from microorganisms (The Golden Age), new antibiotics were found with relative ease from low-throughput fermentation and whole cell screening methods. Later, molecular genetic and medicinal chemistry approaches were applied to modify and improve the activities of important chemical scaffolds, and more sophisticated screening methods were directed at target disease states. In the 1990s, the pharmaceutical industry moved to high-throughput screening of synthetic chemical libraries against many potential therapeutic targets, including new targets identified from the human genome sequencing project, largely to the exclusion of natural products, and discovery rates dropped dramatically. Nonetheless, natural products continued to provide key scaffolds for drug development. In the current millennium, it was discovered from genome sequencing that microbes with large genomes have the capacity to produce about ten times as many secondary metabolites as was previously recognized. Indeed, the most gifted actinomycetes have the capacity to produce around 30–50 secondary metabolites. With the precipitous drop in cost for genome sequencing, it is now feasible to sequence thousands of actinomycete genomes to identify the “biosynthetic dark matter” as sources for the discovery of new and novel secondary metabolites. Advances in bioinformatics, mass spectrometry, proteomics, transcriptomics, metabolomics and gene expression are driving the new field of microbial genome mining for applications in natural product discovery and development.
The amount of plastics disposed from modern lifestyles have increased sharply in recent years. Solid biomass is an abundant energy resource that exists worldwide. Transformation of these waste ...plastics and solid biomass feedstock mixtures via co-pyrolysis can provide synergistic product enhancement for fuels and value-added products. The produced products can be used as chemicals and pollutant sorbents to foster eco-friendly pathways for waste management and sustainability. Progress into this avenue of waste disposal and energy production is the focus of this review. Properties of characteristic solid feedstock mixtures are discussed with focus on elemental composition, proximate analysis, and heating value. Effective H to C ratio of the different feedstocks is evaluated for asserting the quality of petrochemical equivalent products produced from co-pyrolysis of plastic wastes and biomass. The characteristics of polyethylene terephthalate (PET), high density and low-density polyethylene (HDPE & LDPE), polyvinyl chloride (PVC), polypropylene (PP), polystyrene (PS) and other major plastic waste components are discussed with focus on synergistic effects attainable by co-pyrolyzing them with biomass. State-of-the-art experimental methods for co-pyrolysis investigation are reviewed in detail using TGA, pyrolyzer, fixed bed reactor, fluidized bed reactor, microwave, and multi-step reactors using GC, MS, and FTIR diagnostics. In addition, different catalytic co-pyrolysis reactors are compared and discussed at different ratios of feedstock to catalyst, reactor temperature, and other operational parameters along with an in-depth understanding of several catalytic processing (ZSM-5 based catalyst, transition metal-based catalyst, multipurpose catalysts and ex-situ catalyst) for favorable products yield. Co-pyrolysis of waste plastic and solid biomass mixtures are reviewed for insights into liquid products for fuels and chemicals, as well as yield and composition of gases and solid residues evolved along with surface characteristics of the solid residues obtained from the selected configurations. The challenges and opportunities envisioned for the development in co-pyrolysis of several solid organic waste and plastic feedstock mixtures are also discussed. The goal was to provide favorable feasible pathways for clean and efficient disposal of plastic wastes with the incorporation of waste biomass for enhanced synergistic effects in waste disposal along with the recovery of energy and value-added products.
The oil curse Ross, Michael L
2012., 20120304, 2012, 2012-03-04, 20130101
eBook
Countries that are rich in petroleum have less democracy, less economic stability, and more frequent civil wars than countries without oil. What explains this oil curse? And can it be fixed? In this ...groundbreaking analysis, Michael L. Ross looks at how developing nations are shaped by their mineral wealth--and how they can turn oil from a curse into a blessing.
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