Cell cycle progression during development is meticulously coordinated with differentiation. This is particularly evident in the Drosophila 3rd instar eye imaginal disc, where the cell cycle is ...synchronized and arrests at the G1 phase in the non-proliferative region (NPR), setting the stage for photoreceptor cell differentiation. Here, we identify the transcription factor Nuclear Factor-YC (NF-YC) as a crucial player in this finely tuned progression, elucidating its specific role in the synchronized movement of the morphogenetic furrow. Depletion of NF-YC leads to extended expression of Cyclin A (CycA) and Cyclin B (CycB) from the FMW to the NPR. Notably, NF-YC knockdown resulted in decreased expression of Eyes absent (Eya) but did not affect Decapentaplegic (Dpp) and Hedgehog (Hh). Our findings highlight the role of NF-YC in restricting the expression of CycA and CycB in the NPR, thereby facilitating cell-cycle synchronization. Moreover, we identify the transcriptional cofactor Eya as a downstream target of NF-YC, revealing a new regulatory pathway in Drosophila eye development. This study expands our understanding of NF-YC’s role from cell cycle control to encompass developmental processes.
The US Food and Drug Administration has approved the use of plasma from recovered patients to treat people who are critically ill with covid-19, provided that doctors get approval over the ...telephone.1 The method has been used in the past to treat diseases such as polio, measles, and mumps, in the 1918 flu epidemic, and in previous outbreaks of respiratory infections similar to covid-19. New York officials said they would recruit patients who have recovered from covid-19, probably from the New York City suburb where the state’s outbreak began, NBC News reported.2 Cuomo said it was a trial to treat people in a serious condition. ...given the current public health emergency, the FDA said it was providing emergency access to convalescent plasma for patients “with serious or immediately life threatening covid-19 infections.”
This work presents a method to produce conductive and auxetic composite membranes from a biobased and biodegradable matrix: polybutylene succinate (PBS). The conductivity was improved by the addition ...of graphene nanoplatelets (GNP) and the samples were produced via solution electrospinning. The membrane properties were shown to increase with increasing GNP concentration and the rotational speed of the collector. In particular, a membrane having 0.2% w/v GNP and fabricated at the highest collector speed (9.96 m/s) showed the highest electrical conductivity (1.56 * 10.sup.-4 S/m) while having a negative Poisson's ratio (NPR) of -1.5 in tension. To complete the analysis, mechanical characterizations showed that the presence of GNP led to a substantial increase in Young's modulus (234%) and tensile strength (190%) compared to the neat PBS membrane produced under the same conditions. Differential scanning calorimetry (DSC) revealed a slight crystallinity increase since GNP are acting as heterogeneous nucleating agents, while thermogravimetric analysis (TGA) showed an improved thermal stability for the GNP/PBS membranes. This unique combination of auxetic and conductive properties can be useful for a wide range of innovative applications such as electronic devices, smart textiles, biomaterials, and biomedical devices.
New Deal Radio Hayes, Joy Elizabeth; Goodman, David
05/2022
eBook
New Deal Radio examines the federal government's
involvement in broadcasting during the New Deal period, looking at
the U.S. Office of Education's Educational Radio Project. The fact
that the United ...States never developed a national public
broadcaster, has remained a central problem of US broadcasting
history. Rather than ponder what might have been, authors Joy Hayes
and David Goodman look at what did happen. There was in fact a
great deal of government involvement in broadcasting in the US
before 1945 at local, state, and federal levels. Among the federal
agencies on the air were the Department of Agriculture, the
National Park Service, the Works Progress Administration (WPA) and
the Federal Theatre Project. Contextualizing the different series
aired by the Educational Radio Project as part of a unified project
about radio and citizenship is crucial to understanding them.
New Deal Radio argues that this distinctive government
commercial partnership amounted to a critical intervention in US
broadcasting and an important chapter in the evolution of public
radio in America.
In this article we will look at a practice-as-research collaboration between us Author A, Author B, Eddie Ladd and formerly Karoline Gritzner which explored the aesthetics of neo-medievalism through ...an intermedial dramaturgy and digital scenography. Currently the project has two forms, an intermedial theatrical version of Author A's radio play Our Lady of Shadows (broadcast on BBC Radio 3), which is a radical adaptation of Alfred Tennyson's famous poem, The Lady of Shalott and an augmented reality version of the radio play which also functions as its documentation. The work combines dramatic text, physical performance, digital scenography, painting, animation and music in an intermedial exploration of the tenuous pact between reality and imagination.In the first instance we will introduce the project and then we will explore how Karen Barad’s concept of ‘diffraction’ can form the basis of a dramaturgical approach as suggested by Vlad Butucea (2022) and analyse how it manifests itself in our practice-as-research. Even though Barad’s concept is an analytical methodology in her writing, we are wondering what a concept of a ‘diffractive dramaturgy’ would be like, one that is based on the interferences between layers of technology and live performance? As such we will attempt to present our research findings in the form of a manifesto for a ‘diffractive dramaturgy’. In the final section of the article, we will explore the wider cultural and political implications of this project by framing it through Katherine Hayles’ concept of the ‘posthuman’.
Mark Christ of the Arkansas Historic Preservation Program, who worked with Fry on the Arkansas Civil War Sesquicentennial Minutes, praised Fry's radio editing skills but summed up his feelings this ...way: "He was my friend and I will miss him." Steward said Fry had been instrumental in securing a $278,000 grant to KUAR and three other NPR stations in Arkansas for establishing a statewide public radio collaboration, Natural State News, designed to reach rural listeners.
Excess meat consumption, particularly of red and processed meats, is associated with nutritional and environmental health harms. While only a small portion of the population is vegetarian, surveys ...suggest many Americans may be reducing their meat consumption. To inform education campaigns, more information is needed about attitudes, perceptions, behaviours and foods eaten in meatless meals.
A web-based survey administered in April 2015 assessed meat reduction behaviours, attitudes, what respondents ate in meatless meals and sociodemographic characteristics.
Nationally representative, web-based survey in the USA.
US adults (n 1112) selected from GfK Knowledgeworks' 50 000-member online panel. Survey weights were used to assure representativeness.
Two-thirds reported reducing meat consumption in at least one category over three years, with reductions of red and processed meat most frequent. The most common reasons for reduction were cost and health; environment and animal welfare lagged. Non-meat reducers commonly agreed with statements suggesting that meat was healthy and 'belonged' in the diet. Vegetables were most often consumed 'always' in meatless meals, but cheese/dairy was also common. Reported meat reduction was most common among those aged 45-59 years and among those with lower incomes.
The public and environmental health benefits of reducing meat consumption create a need for campaigns to raise awareness and contribute to motivation for change. These findings provide rich information to guide intervention development, both for the USA and other high-income countries that consume meat in high quantities.
Mobile fronthaul is an important network segment that bridges wireless baseband units and remote radio units to support cloud radio access network. We review recent progresses on the use of ...frequency-division multiplexing to achieve highly bandwidth-efficient mobile fronthaul with low latency. We present digital signal processing (DSP) techniques for channel aggregation and deaggregation, frequency-domain windowing, adjacent channel leak age ratio reduction, and synchronous transmission of both the I/Q waveforms of wireless signals and the control words (CWs) used for control and management purposes. In a proof-of-concept experiment, we demonstrate the transmission of 48 20-MHz LTE signals with a common public radio interface (CPRI) equivalent data rate of 59 Gb/s, achieving a low round-trip DSP latency of <;2 μs and a low mean error-vector magnitude (EVM) of ~2.5% after fiber transmission. In a follow-up experiment, we further demonstrate the transmission of 32 20-MHz LTE signals together with CPRI-compliant CWs, corresponding to a CPRI-equivalent data rate of 39.32 Gb/s, in single optical wavelength channel that requires an RF bandwidth of only ~1.6 GHz. After transmission over 5-km standard single-mode fiber, the CWs are recovered without error, while the LTE signals are recovered with an EVM of lower than 3%. Applying this technique to future 5G wireless networks with massive multiple-input multiple-output is also discussed. This efficient mobile fronthaul technique may find promising applications in future integrated fiber/wireless access networks to provide ultrabroadband access services.
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