Objective
To explore the feasibility of high-throughput massively parallel genomic DNA sequencing technology for the noninvasive prenatal detection of fetal sex chromosome aneuploidies (SCAs).
...Methods
The study enrolled pregnant women who were prepared to undergo noninvasive prenatal testing (NIPT) in the second trimester. Cell-free fetal DNA (cffDNA) was extracted from the mother’s peripheral venous blood and a high-throughput sequencing procedure was undertaken. Patients identified as having pregnancies associated with SCAs were offered prenatal fetal chromosomal karyotyping.
Results
The study enrolled 10 275 pregnant women who were prepared to undergo NIPT. Of these, 57 pregnant women (0.55%) showed fetal SCA, including 27 with Turner syndrome (45,X), eight with Triple X syndrome (47,XXX), 12 with Klinefelter syndrome (47,XXY) and three with 47,XYY. Thirty-three pregnant women agreed to undergo fetal karyotyping and 18 had results consistent with NIPT, while 15 patients received a normal karyotype result. The overall positive predictive value of NIPT for detecting SCAs was 54.54% (18/33) and for detecting Turner syndrome (45,X) was 29.41% (5/17).
Conclusion
NIPT can be used to identify fetal SCAs by analysing cffDNA using massively parallel genomic sequencing, although the accuracy needs to be improved particularly for Turner syndrome (45,X).
Placing sexual culture at the center of power relations in Revolutionary-era Philadelphia, Clare A. Lyons uncovers a world where runaway wives challenged their husbands' patriarchal rights and where ...serial and casual sexual relationships were commonplace. By reading popular representations of sex against actual behavior, Lyons reveals the clash of meanings given to sex and illuminates struggles to recast sexuality in order to eliminate its subversive potential. Sexuality became the vehicle for exploring currents of liberty, freedom, and individualism in the politics of everyday life among groups of early Americans typically excluded from formal systems of governance--women, African Americans, and poor classes of whites. Lyons shows that men and women created a vibrant urban pleasure culture, including the eroticization of print culture, as eighteenth-century readers became fascinated with stories of bastardy, prostitution, seduction, and adultery. In the post-Revolutionary reaction, white middle-class men asserted their authority, Lyons argues, by creating a gender system that simultaneously allowed them the liberty of their passions, constrained middle-class women with virtue, and projected licentiousness onto lower-class whites and African Americans. Lyons's analysis shows how class and racial divisions fostered new constructions of sexuality that served as a foundation for gender. This gendering of sexuality in the new nation was integral to reconstituting social hierarchies and subordinating women and African Americans in the wake of the Revolution.
Gender and Politeness challenges the notion that women are necessarily always more polite than men as much of the language and gender literature claims. Sara Mills discusses the complex relations ...between gender and politeness and argues that although there are circumstances when women speakers, drawing on stereotypes of femininity to guide their behaviour, will appear to be acting in a more polite way than men, there are many circumstances where women will act just as impolitely as men. The book aims to show that politeness and impoliteness are in essence judgements about another's interventions in an interaction and about that person as whole, and are not simple classifications of particular types of speech. Drawing on the notion of community of practice Mills examines the way that speakers negotiate with what they perceive to be gendered stereotypes circulating within their particular group.
Is it time to take a break from feminism? In this pathbreaking book, Janet Halley reassesses the place of feminism in the law and politics of sexuality. She argues that sexuality involves deeply ...contested and clashing realities and interests, and that feminism helps us understand only some of them. To see crucial dimensions of sexuality that feminism does not reveal--the interests of gays and lesbians to be sure, but also those of men, and of constituencies and values beyond the realm of sex and gender--we might need to take a break from feminism. Halley also invites feminism to abandon its uncritical relationship to its own power. Feminists are, in many areas of social and political life, partners in governance. To govern responsibly, even on behalf of women, Halley urges, feminists should try taking a break from their own presuppositions. Halley offers a genealogy of various feminisms and of gay, queer, and trans theories as they split from each other in the United States during the 1980s and 1990s. All these incommensurate theories, she argues, enrich thinking on the left not despite their break from each other but because of it. She concludes by examining legal cases to show how taking a break from feminism can change your very perceptions of what's at stake in a decision and liberate you to decide it anew.
Focusing the perspectives of gender scholarship on the study of empire, this is a volume of insights about the conduct of men as well as women. Bringing together disparate fields — politics, ...medicine, sexuality, childhood, religion, migration, and many more topics — this collection of essays demonstrates the richness of studying empire through the lens of gender. This is a more inclusive look at empire, which asks not only why the empire was dominated by men, but how that domination affected the conduct of imperial politics.
Sexing the Caribbean Kempadoo, Kamala
2004, 20041201, 2004-12-01, 20040101
eBook
This unprecedented work provides both the history of sex work in this region as well as an examination of current-day sex tourism. Based on interviews with sex workers, brothel owners, local ...residents and tourists, Kamala Kempadoo offers a vivid account of what life is like in the world of sex tourism as well as its entrenched roots in colonialism and slavery in the Caribbean.
Kamala Kempadoo is a Professor at York University in Ontario. She was the Acting Director and Lecturer at the Centre for Gender and Development Studies at the University of West Indies--Mona in Jamaica. She is the editor of Global Sex Workers (Routledge, 1998) and Sun, Sex and Gold (1999).
Gender and sexuality have been neglected topics in the history of Chinese civilization, despite the fact that there is a massive amount of historical evidence on the subject. China's late imperial ...government was arguably more concerned about gender and sexuality among its subjects than any other pre-modern state. How did these and other late imperial legacies shape twentieth-century notions of gender and sexuality in modern China? Susan Mann answers this by focusing on state policy, ideas about the physical body and notions of sexuality and difference in China's recent history, from medicine to the theater to the gay bars; from law to art and sports. More broadly, the book shows how changes in attitudes toward sex and gender in China during the twentieth century have cast a new light on the process of becoming modern, while simultaneously challenging the universalizing assumptions of Western modernity.
Sex workers are at disproportionate risk of violence and sexual and emotional ill health, harms that have been linked to the criminalisation of sex work. We synthesised evidence on the extent to ...which sex work laws and policing practices affect sex workers' safety, health, and access to services, and the pathways through which these effects occur.
We searched bibliographic databases between 1 January 1990 and 9 May 2018 for qualitative and quantitative research involving sex workers of all genders and terms relating to legislation, police, and health. We operationalised categories of lawful and unlawful police repression of sex workers or their clients, including criminal and administrative penalties. We included quantitative studies that measured associations between policing and outcomes of violence, health, and access to services, and qualitative studies that explored related pathways. We conducted a meta-analysis to estimate the average effect of experiencing sexual/physical violence, HIV or sexually transmitted infections (STIs), and condomless sex, among individuals exposed to repressive policing compared to those unexposed. Qualitative studies were synthesised iteratively, inductively, and thematically. We reviewed 40 quantitative and 94 qualitative studies. Repressive policing of sex workers was associated with increased risk of sexual/physical violence from clients or other parties (odds ratio OR 2.99, 95% CI 1.96-4.57), HIV/STI (OR 1.87, 95% CI 1.60-2.19), and condomless sex (OR 1.42, 95% CI 1.03-1.94). The qualitative synthesis identified diverse forms of police violence and abuses of power, including arbitrary arrest, bribery and extortion, physical and sexual violence, failure to provide access to justice, and forced HIV testing. It showed that in contexts of criminalisation, the threat and enactment of police harassment and arrest of sex workers or their clients displaced sex workers into isolated work locations, disrupting peer support networks and service access, and limiting risk reduction opportunities. It discouraged sex workers from carrying condoms and exacerbated existing inequalities experienced by transgender, migrant, and drug-using sex workers. Evidence from decriminalised settings suggests that sex workers in these settings have greater negotiating power with clients and better access to justice. Quantitative findings were limited by high heterogeneity in the meta-analysis for some outcomes and insufficient data to conduct meta-analyses for others, as well as variable sample size and study quality. Few studies reported whether arrest was related to sex work or another offence, limiting our ability to assess the associations between sex work criminalisation and outcomes relative to other penalties or abuses of police power, and all studies were observational, prohibiting any causal inference. Few studies included trans- and cisgender male sex workers, and little evidence related to emotional health and access to healthcare beyond HIV/STI testing.
Together, the qualitative and quantitative evidence demonstrate the extensive harms associated with criminalisation of sex work, including laws and enforcement targeting the sale and purchase of sex, and activities relating to sex work organisation. There is an urgent need to reform sex-work-related laws and institutional practices so as to reduce harms and barriers to the realisation of health.
According to the simple scenario, the presence or absence of a Y chromosome is what counts: with it, you are male, and without it, you are female. Gene mutations affecting gonad development can ...result in a person with XY chromosomes developing typically female characteristics, whereas alterations in hormone signalling can cause XX individuals to develop along male lines.
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