A central element of interdependence theory is that people have standards against which they compare their current outcomes, and one ubiquitous standard in the mating domain is the preference for ...particular attributes in a partner (ideal partner preferences). This article reviews research on the predictive validity of ideal partner preferences and presents a new integrative model that highlights when and why ideals succeed or fail to predict relational outcomes. Section 1 examines predictive validity by reviewing research on sex differences in the preference for physical attractiveness and earning prospects. Men and women reliably differ in the extent to which these qualities affect their romantic evaluations of hypothetical targets. Yet a new meta-analysis spanning the attraction and relationships literatures (k = 97) revealed that physical attractiveness predicted romantic evaluations with a moderate-to-strong effect size (r = ∼.40) for both sexes, and earning prospects predicted romantic evaluations with a small effect size (r = ∼.10) for both sexes. Sex differences in the correlations were small (rdifference = .03) and uniformly nonsignificant. Section 2 reviews research on individual differences in ideal partner preferences, drawing from several theoretical traditions to explain why ideals predict relational evaluations at different relationship stages. Furthermore, this literature also identifies alternative measures of ideal partner preferences that have stronger predictive validity in certain theoretically sensible contexts. Finally, a discussion highlights a new framework for conceptualizing the appeal of traits, the difference between live and hypothetical interactions, and the productive interplay between mating research and broader psychological theories.
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CEKLJ, FFLJ, NUK, ODKLJ, PEFLJ
Abstract
Genome sequencing and genetic mapping of molecular markers have demonstrated nearly complete Y-linkage across much of the guppy (Poecilia reticulata) XY chromosome pair. Predominant ...Y-linkage of factors controlling visible male-specific coloration traits also suggested that these polymorphisms are sexually antagonistic (SA). However, occasional exchanges with the X are detected, and recombination patterns also appear to differ between natural guppy populations, suggesting ongoing evolution of recombination suppression under selection created by partially sex-linked SA polymorphisms. We used molecular markers to directly estimate genetic maps in sires from 4 guppy populations. The maps are very similar, suggesting that their crossover patterns have not recently changed. Our maps are consistent with population genomic results showing that variants within the terminal 5 Mb of the 26.5 Mb sex chromosome, chromosome 12, are most clearly associated with the maleness factor, albeit incompletely. We also confirmed occasional crossovers proximal to the male-determining region, defining a second, rarely recombining, pseudo-autosomal region, PAR2. This fish species may therefore have no completely male-specific region (MSY) more extensive than the male-determining factor. The positions of the few crossover events suggest a location for the male-determining factor within a physically small repetitive region. A sex-reversed XX male had few crossovers in PAR2, suggesting that this region's low crossover rate depends on the phenotypic, not the genetic, sex. Thus, rare individuals whose phenotypic and genetic sexes differ, and/or occasional PAR2 crossovers in males can explain the failure to detect fully Y-linked variants.
46, XY disorders of sex development (46, XY DSD) are congenital disorders with 46, XY chromosomal karyotype but inconsistent gonadal/phenotypic sex. One of the biggest concerns for parents and ...clinicians is the gender assignment. However, there is no standard uniform of care nor consensus at present. We sought to evaluate the current treatment's rationality and provide a reference basis for the gender reassignment in 46, XY DSD patients with a specific diagnosis.
We conducted a cross-sectional survey of gender role with the Pre-school Activities Inventory (PSAI), the Children's Sex Role Inventory (CSRI) in 46, XY DSD patients and set up control groups comparison. Psychiatrist assessed gender dysphoria in patients ≥ 8-year-old with the criteria of diagnostic and statistical manual of mental disorders, 5th edition (DSM-5).
A total of 112 responders of 136 patients participated in this study (82.4%, aged 2-17.8 years, median age: 4-year-old). The follow-up period was from 6 months to 10 years (median: 2 years). Twenty-five females were reassigned to the male gender after a specific diagnosis (16/25 (64%) in 5 alfa-reductase-2 deficiency (5α-RD2), 5/25 (20%) in partial androgen insensitivity syndrome (PAIS), 4/25 (16%) in NR5A1gene mutation). Male gender assignment increased from 55.3 (n = 62) to 77.7% (n = 87). The median PSAI score was similar to the control males in 5α-RD2, PAIS, and NR5A1 gene mutation groups (p > 0.05); while identical to the control females in complete androgen insensitivity syndrome (CAIS) and CYP17A1 gene mutation groups (p > 0.05). PSAI score of children raised as male was higher than those of CAIS and CYP17A1 groups raised as female (p < 0.05). CSRI scale showed no statistical differences in the consistency of gender roles and reassigned gender between 46, XY DSD patients and control groups (p > 0.05). None of the patients over 8-year-old (n = 44) had gender dysphoria.
The reassigned gender in 46, XY DSD patients is consistent with their gender role during early childhood. None of them had gender dysphoria. The molecular diagnosis, gonadal function, and the gender reassignment are congruent within our Chinese cohort. Long-term follow-up and more evaluation are still required.
Sex determination is a fundamentally important and highly diversified biological process, yet the mechanisms behind the origin of this diversity are mostly unknown. Here we suggest that the evolution ...of sex determination systems can be driven by a chromosomal inversion. We show that an XY system evolved recently in particular nine-spined stickleback (Pungitius pungitius) populations, which arose from ancient hybridization between two divergent lineages. Our phylogenetic and genetic mapping analyses indicate that the XY system is formed in a large inversion that is associated with hybrid sterility between the divergent lineages. We suggest that a new male-determining gene evolved in the inversion in response to selection against impaired male fertility in a hybridized population. Given that inversions are often associated with hybrid incompatibility in animals and plants, they might frequently contribute to the diversification of sex determination systems.
Background
The recent emergence of COVID-19 poses a global health emergency. One of the most frequently reported data is sex-related severity and mortality: according to the last available analysis ...on 239,709 patients in Italy, lethality is 17.7% in men and 10.8% in women, with 59% of total deaths being men. Interestingly, the infection rate is lower in males than in females, with 45.8% and 54.2% of positive cases, respectively, suggesting that gender-related factor may worsen disease evolution. A tentative hypothesis to explain these findings is the role of angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 involved in viral infection.
Purpose
In this review, we summarize the available evidence pointing to gender-related differences in ACE2 and TMPRSS2 expression, from both genetic and endocrine points of view.
Results
Altogether, available evidence points toward two not-mutually exclusive mechanisms in gender susceptibility to COVID-19 by sex hormonal regulation of ACE2 and TMPRSS2. On one hand, ACE2 expression could be increased in women, either by estrogens or constitutively by X chromosome inactivation escape or by reduced methylation, providing a larger reservoir of ACE2 to maintain the fundamental equilibrium of RAS regulatory axis. On the other, low levels of androgens in women may keep at low levels TMPRSS2 expression, representing a further protective factor for the development of COVID-19 infection, despite the increased expression of ACE2, which represents the Trojan horse for SARS-CoV-2 entry.
Conclusions
Both mechanisms consistently point to the role of sex hormones and sex chromosomes in the differential severity and lethality of COVID-19 in men and women.
For much of Chinese history, the eunuch stood out as an exceptional figure at the margins of gender categories. Amid the disintegration of the Qing Empire, men and women in China began to understand ...their differences in the language of modern science. InAfter Eunuchs, Howard Chiang traces the genealogy of sexual knowledge from the demise of eunuchism to the emergence of transsexuality, showing the centrality of new epistemic structures to the formation of Chinese modernity.From anticastration discourses in the late Qing era to sex-reassignment surgeries in Taiwan in the 1950s and queer movements in the 1980s and 1990s,After Eunuchsexplores the ways the introduction of Western biomedical sciences transformed normative meanings of gender, sexuality, and the body in China. Chiang investigates how competing definitions of sex circulated in science, medicine, vernacular culture, and the periodical press, bringing to light a rich and vibrant discourse of sex change in the first half of the twentieth century. He focuses on the stories of gender and sexual minorities as well as a large supporting cast of doctors, scientists, philosophers, educators, reformers, journalists, and tabloid writers, as they debated the questions of political sovereignty, national belonging, cultural authenticity, scientific modernity, human difference, and the power and authority of truths about sex. Theoretically sophisticated and far-reaching,After Eunuchsis an innovative contribution to the history and philosophy of science and queer and Sinophone studies.
Porno-Graphics and Porno-Tactics asks whether, and how, it is possible to re-appropriate pornography and think through it critically and creatively for a project of liberation. In the different ...contributions which make up this deliberately heterogeneous collection of short, non-canonical essays, such a quest proceeds by re-articulating the aporias of desire, intimacy, touch and seduction. It also relates them to claims of visibility, visions of emancipation and its failures, as well as to the politics of violence that we get exposed to through circulating images and affects. This is an attempt to exceed the limits set by and for ourselves in relation to how we connect to our own bodies, to the bodies of our lovers and to the bodies of the theories we live with, sleep with and dream about – in short, to all that we get attached to. The editors and contributors of this collection do not claim the euphoric potentiality of pornography as necessarily subversive and emancipatory, but are nevertheless open to the possibilities of re-shaping it (in textual, contextual, intertextual, but also affective and embodied forms) through different graphic and tactical/tactile inscriptions. On the one hand, authors reflect on definitions and practices of pornography as a genre adopting specific codes and canons, whether it is concerned with sex acts and the industry of porn or with other predominant forms of representation and the structures of power underlying them. On the other hand, chapters relate to the more affective, libidinal, synaesthetic and inter/subjective dimensions of pornography, and on the capacity of different reappropriations to subvert its limits.
Polygenic sex determination (PSD) is defined as the determination of sexual phenotype by the combined action of two or more genes at independently inherited loci in one individual.PSD should not be ...ascribed to multiple alleles at the same sex determination (SD) locus that may be polymorphic in the population, elements of a common biochemical pathway, and to multiple sex chromosomes that are polymorphic in a population, or neo-sex chromosomes or sex chromosome chains when sexual development of the individuum is triggered by one SD locus.A consistent nomenclature that adheres to accepted definitions of genes and alleles is recommended.Evolutionary theory predicts that PSD is an unstable state.Documented cases of PSD are rare. Those examined are best explained by transitionary stages during sex chromosome turnover or aberrant situations in hybrids between species with different sex chromosomes.
Genetic sex determination (SD) in most vertebrates is controlled by a single master sex gene, which ensures a 1:1 sex ratio. However, more complex systems abound, and several have been ascribed to polygenic SD (PSD), in which many genes at different loci interact to produce the sexual phenotype. Here we examine claims for PSD in vertebrates, finding that most constitute transient states during sex chromosome turnover, or aberrant systems in species hybrids. To avoid confusion about terminology, we propose a consistent nomenclature for genetic SD systems.
Abstract
Estrogen signaling exerts a decisive role in female sex determination and differentiation in chicken and fish. Aromatase encoded by Cyp19a1 is the key enzyme that catalyzes the conversion of ...androgen to estrogen. Correlative analyses implicate the potential involvement of aromatase in reptilian sexual development, however, the direct genetic evidence is lacking. Herein, we found that Cyp19a1 exhibited temperature-dependent sexually dimorphic expression, and located in the medullary somatic cells in early female embryos of the red-eared slider turtle (Trachemys scripta elegans), before the gonad is distinct. To determine the functional role of Cyp19a1 in turtle ovarian determination, we established loss- and gain-of-function models through in ovo lentivirus-mediated genetic manipulation. At female-producing temperature, inhibition of aromatase or knockdown of Cyp19a1 in turtle embryos resulted in female-to-male sex reversal, with the formation of a testis-like structure and a male distribution pattern of germ cells, as well as ectopic expression of male-specific markers (SOX9 and AMH) and disappearance of ovarian regulator FOXL2. On the contrary, overexpression of Cyp19a1 at male-producing temperature led to male-to-female sex reversal. In conclusion, our results suggest that Cyp19a1 is both necessary and sufficient for ovarian determination in the red-eared slider turtle, establishing causality and a direct genetic link between aromatase and reptilian sex determination and differentiation.
Traditionally, scholars have approached Roman sexuality using categories of sexual ethics drawn from contemporary, Western society. In this 2006 book Dr Langlands seeks to move away from these ...towards a deeper understanding of the issues that mattered to the Romans themselves, and the ways in which they negotiated them, by focusing on the untranslatable concept of pudicitia (broadly meaning 'sexual virtue'). She offers a series of nuanced close readings of texts from a wide spectrum of Latin literature, including history, oratory, love poetry and Valerius Maximus' work Memorable Deeds and Sayings. Pudicitia emerges as a controversial and unsettled topic, at the heart of Roman debates about the difference between men and women, the relation between mind and body, and the ethics of power and status differentiation within Roman culture. The book develops strategies for approaching the study of an ancient culture through sensitive critical readings of its literary productions.
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