The purpose of this study was to investigate the construct validity of the 2-minute walk test (2MWT) to assess the exercise capacity and the criterion-concurrent validity of the 2MWT and the 6-minute ...walk test (6MWT) to estimate the cardiorespiratory fitness of ambulatory individuals with chronic stroke. In addition, to provide an equation to predict the distance covered in the 6MWT and another to predict the peak oxygen consumption (VO
2peak
) for these individuals.
This is a cross-sectional and prospective study. A convenience sample with 57 individuals with chronic stroke was recruited. The 2MWT, the 6MWT and the cardiopulmonary exercise test (CPET) were performed in a laboratory. The Spearman's correlation coefficient was used to investigate the validity. To develop the equations, stepwise multiple linear regression analysis was used.
A significant correlation of very high magnitude between the distance covered in the 2MWT and the 6MWT was found (r
s
= 0.93; p < 0.001). A significant correlation of moderate magnitude between the distance covered in the 2MWT and the VO
2peak
(r
s
= 0.53; p < 0.001) similar to the correlation between the 6MWT and the VO
2peak
(r
s
= 0.55; p < 0,001) were found. Furthermore, an equation was developed to predict the VO
2peak
(R
2
= 0.690; p < 0.001; VO
2peak
= 13.532 + 0.078*distance walked in the 2MWT +4.509*sex-0.172*age), and another to predict the distance covered in the 6MWT (R
2
= 0.827; p < 0.001; MWT = −1.867 + 3.008*distance walked in the 2MWT).
2MWT showed adequate construct and concurrent validity. Furthermore, it is possible to use the prediction equations developed to estimate the VO
2peak
or the distance covered in the 6MWT.
•Older adults show increased gait variability during 6 and 2-minute walking tests.•Two-minute walk tests (2MWT) demonstrate similar results to a six-minute walk test.•2MWT may offer an ideal choice ...for both clinical and research gait assessment.
The six-minute walk test (6MWT) is used within clinical and research settings to assess gait performance across a variety of conditions and populations. Commonly, the test is used to identify specific aspects of gait that affect functional mobility. With the advancement of new technologies such as wireless inertial sensors, it has become possible to collect reliable, sensitive, and objective measures of gait. While the 6MWT has been accepted and used for many years, a more concise, while still objective gait analysis would likely benefit clinicians, researchers and patients.
Does a concise 2-minute walk test (2MWT) provide similar information regarding gait performance and gait differences as the 6MWT in healthy young (YA) and older adults (OA)?
A total of thirty-one participants (sixteen young adults and fifteen older adults) conducted a continuous 6MWT at their self-selected pace. All participants wore six wireless inertial sensors which were placed on each foot, at the lumbar, sternum, and on each wrist. Once completed the 6MWT data was spliced into three, distinct two-minute segments. Spliced data was analyzed and compared between groups and segments.
Results demonstrate significant age-related differences in several gait metrics, primarily with older adults showing increased spatiotemporal variability. Additionally, no significant differences were observed between the three, two-minute segments and the continuous 6MWT, with the exception of total number of strides completed.
These results demonstrate that the 2MWT may provide a preferable alternative to assessing gait performance by reducing confounds such as fatigue while maintaining sensitivity of measuring gait performance. These improvements may be particularly beneficial when studying populations of advanced age or with neurological disorder.
Outcomes of users provided with a commercial ESR Vari-Flex foot (Össur, Reykjavik, Iceland) and a locally designed sPace foot were investigated. Step activity with users' own prosthetic foot compared ...to the sPace foot was explored.
Eleven individuals with unilateral trans-tibial amputation participated and were provided with an sPace and Vari-Flex foot. Ten- and twenty-meter walk tests (10/20MWT) at comfortable and fast walking speeds (CWS/FWS), the two-minute walk test (2-MWT) and Comprehensive High-Level Activity Mobility Predictor (CHAMP) were administered. A subgroup was provided a pedometer to record their steps over a 7-day period in their own foot and later the sPace.
The sPace foot performed well in a battery of high-level mobility outcome measures. On CHAMP, participants scored 16.94 ± 5.41 and 16.72 ± 6.09 with the sPace and Vari-Flex feet, respectively. Subgroup testing of step activity showed 4490 ± 3444 steps in users' own feet and 3115 ± 1967 in the sPace foot,
= 0.176.
Participants using the sPace foot were capable of performing walking, high-level mobility and activity outcome measures.
Purpose:
Performance-based outcome measures are becoming increasingly important in health care. The 2-minute walk test (2MWT) and the Timed Up and Go test (TUG) are frequently used in clinical trials ...as performance-based tests in many diseases including osteoarthritis. The purposes of this study were: (1) to determine test-retest reliability of data for the 2MWT and the TUG; (2) to determine minimal detectable change (MDC) scores for the TUG and 2MWT in patients with total hip arthroplasty (THA).
Methods:
37 patients, who had undergone primary THA, were included. Patients twice performed trials for the 2MWT and TUG on the same day. In addition to demographic data of patients, the Harris Hip Score, 2MWT and TUG scores were recorded.
Results:
The TUG and 2MWT showed excellent test-retest reliability. The Intraclass correlation coefficient ICC (2,1), Standard error of measurement (SEM) and minimal detectable chance at the 95% CI (MDC95) for TUG were 0.96, 0.59 seconds and 1.62 seconds respectively. The ICC (2,1), SEM and MDC95 for 2MWT were 0.96, 6.37 m and 17.56 m respectively.
Conclusion:
Clinicians and researchers can be confident that greater changes than 1.62 seconds for TUG and 17.56 m for the 2MWT over time represent a real clinical change in rehabilitation process in patients with THA. Both the 2MWT and TUG may assist in early identification of patients who may need additional rehabilitation to reduce the potential for poor outcomes after THA. Therefore, both of these tests can be used in a clinical setting with a small measurement error.
Introduction: Two-minute walk test (2MWT) is used widely to determine the functional capacity in clinical setup. However, reference equations derived from Western population cannot be applied to ...Indian subjects owing to the ethnic differences. Hence, the current study aimed to establish reference equation for 2MWT in healthy Indian population. Subjects and Methods: A cross-sectional study was conducted in 480 healthy participants in the age group of 20–80 years who performed two 2MWTs using a standardized protocol. The highest value of two-minute walk distance (2MWD) was selected for further analysis. Results: The mean value of 2MWD was 152.33 ± 26.56 m. 2MWD for men (157.3 ± 23.82 m) was higher than females (147.35 ± 28.21 m) (P < 0.001). Bivariate analysis showed that 2MWD correlated significantly (P < 0.05) with age, height, and weight in both genders. Further, stepwise multiple linear regression analysis was performed to generate gender-specific reference equations using age, height, and weight as predictors of 2MWD. Conclusion: We established a gender-specific prediction equation for 2MWD in healthy Indian subjects. It can be used as a reference to interpret functional capacity in patients with acute illness, cardiorespiratory disease, and other health-related conditions.
Background: The repertoire of measures of walking in Rett syndrome is limited. This study aimed to determine measurement properties of a modified two-minute walk test (2MWT) and a modified Rett ...syndrome-specific functional mobility scale (FMS-RS) in Rett syndrome.
Methods: Forty-two girls and women with Rett syndrome (median 18.4 years, range 2.4-60.9 years) were assessed for clinical severity, gross motor skills, and mobility. To measure walking capacity, 27 of this group completed a 2MWT twice on two different assessment days. To assess walking performance, the FMS-RS was administered to the total sample of parents (n = 42) on two occasions approximately one week apart.
Results: There were negative correlations between clinical severity and 2MWT (r = −0.48) and FMS-RS (r = −0.60-0.66). There were positive correlations between gross motor skills and mobility and 2MWT (r = 0.51, 0.43) and FMS-RS (r = 0.71-0.93, 0.74-0.94), respectively. Test-retest reliability for the 2MWT was good with high intraday and interday correlations (ICC = 0.86-0.98). For the 2MWT, the standard error of measurement was 13.8 m and we would be 95% confident that changes greater than 38 m would be greater than within subject error. There was good test-retest reliability for all three distances on the FMS-RS (ICC = 0.94-0.99).
Conclusions: Walking capacity as measured by the 2MWT showed expected but limited relationships with measures of different constructs, providing some support for concurrent validity. Walking performance as measured with the FMS-RS was more strongly consistent with other clinical measures supporting its concurrent validity. Test-retest reliability was good for both the FMS-RS and the 2MWT. Therefore, these measures have the potential to be used in clinical practice and research.
Implications for Rehabilitation
Walking is one of the commonest daily physical activities in ambulant girls and women with RTT. Comprehensive knowledge about the walking abilities in this population is limited.
Evidence of validity and test-retest reliability have been demonstrated for the modified two-minute walk test (2MWT) and the Rett syndrome-specific functional mobility scale (FMS-RS).
The 2MWT and FMS-RS offer detailed information of the capacity and performance of walking, respectively, in girls and women with RTT
The two-minute walk test (2MWT) is a frequently used walking capacity test in persons with multiple sclerosis (pwMS). However, less is known about its relevance with regards to walking capacity ...during free-living walking performance. Therefore, the ecological validity of the 2MWT was tested by 1. computing free-living minutes with the same intensity (cadence) as during the 2MWT and 2. investigating the relationship between 2MWT cadence and minutes with the same cadence during free-living walking. 20 pwMS aged 44.2 ± 12.2 (Expanded Disability Status Scale (EDSS) score of 3.1 ± 1.4) performed a 2MWT and wore an accelerometer for seven days. The number of pwMS reaching 100%, 90%, 80% or 70% of 2MWT cadence for at least one minute a day and minutes/day with at least 100%, 90%, 80% and 70% of 2MWT cadence during free-living walking was calculated. Six participants reached 100% of the 2MWT cadence for at least one minute/day during free-living walking. A total of 80% 2MWT cadence was the first intensity category that was reached by all participants during free-living walking. No significant correlation was found between cadence in the 2MWT and minutes in which this cadence was reached during free-living walking. Ecological validity with regard to walking intensity could not be confirmed in our study sample.
The two-minute walk test (2MWT) is less well validated than the well-known six-minute walk test (6MWT) as a field walking test in patients with chronic obstructive pulmonary disease (COPD). The ...primary objective of this study was to compare the accuracy of the 2MWT to the 6MWT in detecting exercise-induced oxygen desaturation in patients with severe COPD. Twenty-six patients with COPD (age: 61 ± 10 years, forced expired volume in one second: 37 ± 10%) that were normoxemic at rest performed a 2MWT and a 6MWT under normal ambient conditions on two consecutive days in random order. Oxygen saturation, total walking distance, heart rate, breathing frequency, dyspnea, and leg fatigue were evaluated. Average walking distances were 150 m (95% confidence interval (95% CI): 134–165 m) and 397 m (95% CI: 347–447 m) for the 2MWT and 6MWT, respectively (r = 0.80, p < 0.0001). The difference in minimum oxygen saturation during the 2MWT (83%, 95% CI: 81–86%) and 6MWT (mean 82%, 95% CI: 80–84%) was not statistically different and the data strongly correlated between the groups (r = 0.81, p < 0.0001). Other measurements from the 6MWT, including heart rate, breathing rate, and levels of perceived exertion were also comparable in 2MWT. The 2MWT showed comparable validity in detecting exercise-induced oxygen desaturation in patients with severe COPD compared to the 6MWT.
Promoting physical activity should be a priority for patients with systemic lupus erythematosus (SLE) because a sedentary lifestyle compounds patients’ already disproportionately high risk for ...cardiovascular events and other adverse health outcomes. The objectives of this pilot study were to assess physical activity in 50 patients with SLE and to compare activity levels with clinical and psychosocial variables, such as fatigue, depressive symptoms, and social support and stress. Patients were asked open-ended questions about physical activity, and responses were coded according to Grounded Theory. Patients then completed the Paffenbarger Physical Activity and Exercise Index, a survey of lifestyle energy expenditure reported in kilocalories/week, performed a 2-minute walk test according to a standard protocol, and completed questionnaires measuring fatigue, depressive symptoms and social support and stress. Most patients (92%) were women, had a mean age of 45 years, and did not have extensive SLE. In response to open-ended questions, patients reported they avoided physical activity because they did not want to exacerbate SLE in the short term. However, if they could overcome initial hurdles, 46 patients (92%) thought physical activity ultimately would improve SLE symptoms. Walking was the preferred activity and 45 (90%) thought they could walk more. According to the Paffenbarger Index, mean energy expenditure was 1466 ± 1366 kilocalories/week and mean time spent in moderate-intensity activity was 132 ± 222 min/week. In total, 18 patients (36%) and 14 patients (28%) met physical activity goals for these values, respectively. Mean distance walked during the 2-minute test was 149 ± 28 m, equivalent to two blocks, which is similar to reports for stable patients with other chronic diseases. Patients with more social stress and more fatigue reported less physical activity. We conclude that the proportion of patients meeting physical activity goals was low; however, patients performed well on a standard walking test. Most patients believed physical activity provided long-term benefits for SLE and that they could be more physically active.
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