Here, we present the Universal Spectrum Explorer (USE), a web-based tool based on IPSA for cross-resource (peptide) spectrum visualization and comparison (https://www.proteomicsdb.org/use/). Mass ...spectra under investigation can be either provided manually by the user (table format) or automatically retrieved from online repositories supporting access to spectral data via the universal spectrum identifier (USI), or requested from other resources and services implementing a newly designed REST interface. As a proof of principle, we implemented such an interface in ProteomicsDB thereby allowing the retrieval of spectra acquired within the ProteomeTools project or real-time prediction of tandem mass spectra from the deep learning framework Prosit. Annotated mirror spectrum plots can be exported from the USE as editable scalable high-quality vector graphics. The USE was designed and implemented with minimal external dependencies allowing local usage and integration into other web sites (https://github.com/kusterlab/universal_spectrum_explorer).
The Human Proteome Organization’s (HUPO) Human Proteome Project (HPP) developed Mass Spectrometry (MS) Data Interpretation Guidelines that have been applied since 2016. These guidelines have helped ...ensure that the emerging draft of the complete human proteome is highly accurate and with low numbers of false-positive protein identifications. Here, we describe an update to these guidelines based on consensus-reaching discussions with the wider HPP community over the past year. The revised 3.0 guidelines address several major and minor identified gaps. We have added guidelines for emerging data independent acquisition (DIA) MS workflows and for use of the new Universal Spectrum Identifier (USI) system being developed by the HUPO Proteomics Standards Initiative (PSI). In addition, we discuss updates to the standard HPP pipeline for collecting MS evidence for all proteins in the HPP, including refinements to minimum evidence. We present a new plan for incorporating MassIVE-KB into the HPP pipeline for the next (HPP 2020) cycle in order to obtain more comprehensive coverage of public MS data sets. The main checklist has been reorganized under headings and subitems, and related guidelines have been grouped. In sum, Version 2.1 of the HPP MS Data Interpretation Guidelines has served well, and this timely update to version 3.0 will aid the HPP as it approaches its goal of collecting and curating MS evidence of translation and expression for all predicted ∼20 000 human proteins encoded by the human genome.
L’uso dei plastici nel processo di progettazione è stato una pratica comune nel corso della storia che ancora perdura. Nonostante lo sviluppo delle nuove tecnologie e la loro sofisticata capacità di ...rappresentare e prefigurare l’apparenza di ciò che viene progettato, i modelli fisici architettonici continuano ad affascinarci ancora oggi. La loro matericità, insieme alla loro tridimensionalità e alla capacità di riduzione dell’architettura come oggetto fisico, continuano a renderli un veicolo di comunicazione eloquente e uno strumento insostituibile. È difficile immaginare un concorso di una certa importanza in cui gli architetti non presentino modelli o foto degli stessi. Analizziamo qui l’uso dei modelli nel processo di progettazione di Alberto Campo Baeza, l’importanza che hanno in esso e, anche, la possibile influenza che esercitano sul suo stesso lavoro. È necessario aggiungere che i modelli vengono utilizzati nel suo studio per gli scopi più diversi. Qui viene presentata un’analisi dettagliata delle tipologie di modelli utilizzati da Campo Baeza e dei vari scopi comunicativi, espressivi, concettuali, di contestualizzazione, come veicolo per il processo creativo, verifica di effetti di luce, o come strumento eloquente da manipolare, ottenendo una sintesi e una anticipazione di vari aspetti dell’architettura. Nel corso di questa ricerca viene proposta una tassonomia delle tipologie e degli usi dei modelli dell’architetto spagnolo, entrando nel merito delle loro capacità come strumenti di progetto.
U3Si2-UO2 composite fuel combines the advantages of high uranium density and thermal conductivity of U3Si2 and excellent stability of UO2 under light water reactor (LWR) condition. Since ...commercialized pressureless sintering of UO2 is usually performed above the melting point of U3Si2, spark plasma sintering (SPS) is considered as a convenient method to produce U3Si2-UO2 composite fuel. However, the potential interaction between U3Si2 and UO2, an important aspect for composite materials, has not been sufficiently investigated. In this report, U3Si2-UO2 pellets with 1:1 wt ratio were fabricated by SPS. Next, the interaction between U3Si2 and UO2 during the sintering process was examined with X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscope (SEM), and transmission electron microscope (TEM). The results show that U3Si2 and UO2 reacted to yield USi as the main product. The reaction occurred at a relatively low temperature of 1100 °C, at which the composite fuel was less than 90% theoretical density (TD).
Modularity Evaluation (ME) is usually used in community detection for evaluating the disjoint and overlapping communities. In this paper, two obvious defects of ME are revealed and proved, including ...the non-decreasing contribution of isolated nodes to modularity and lacking of appropriate measures on overlapping community. We also propose a new evaluation criterion, the USI-AUC, which is the Area Under the Curve (AUC), originated from link-prediction of Uniform-Structure-Information (USI) model. We test the new criterion on various datasets, and find that such criterion can avoid the issues exposed in ME.
Household coverage with iodized salt was assessed in 10 countries that implemented Universal Salt Iodization (USI).
The objective of this paper was to summarize household coverage data for iodized ...salt, including the relation between coverage and residence type and socioeconomic status (SES).
A review was conducted of results from cross-sectional multistage household cluster surveys with the use of stratified probability proportional to size design in Bangladesh, Ethiopia, Ghana, India, Indonesia, Niger, the Philippines, Senegal, Tanzania, and Uganda. Salt iodine content was assessed with quantitative methods in all cases. The primary indicator of coverage was percentage of households that used adequately iodized salt, with an additional indicator for salt with some added iodine. Indicators of risk were SES and residence type. We used 95% CIs to determine significant differences in coverage.
National household coverage of adequately iodized salt varied from 6.2% in Niger to 97.0% in Uganda. For salt with some added iodine, coverage varied from 52.4% in the Philippines to 99.5% in Uganda. Coverage with adequately iodized salt was significantly higher in urban than in rural households in Bangladesh (68.9% compared with 44.3%, respectively), India (86.4% compared with 69.8%, respectively), Indonesia (59.3% compared with 51.4%, respectively), the Philippines (31.5% compared with 20.2%, respectively), Senegal (53.3% compared with 19.0%, respectively), and Tanzania (89.2% compared with 57.6%, respectively). In 7 of 8 countries with data, household coverage of adequately iodized salt was significantly higher in high- than in low-SES households in Bangladesh (58.8% compared with 39.7%, respectively), Ghana (36.2% compared with 21.5%, respectively), India (80.6% compared with 70.5%, respectively), Indonesia (59.9% compared with 45.6%, respectively), the Philippines (39.4% compared with 17.3%, respectively), Senegal (50.7% compared with 27.6%, respectively) and Tanzania (80.9% compared with 51.3%, respectively).
Uganda has achieved USI. In other countries, access to iodized salt is inequitable. Quality control and regulatory enforcement of salt iodization remain challenging. Notable progress toward USI has been made in Ethiopia and India. Assessing progress toward USI only through household salt does not account for potentially iodized salt consumed through processed foods.
Open-Metric for Unknown Signal Inference Li, Xinyu; Liu, Lutao; Zheng, Yu
IEEE transactions on aerospace and electronic systems,
10/2023, Volume:
59, Issue:
5
Journal Article
Peer reviewed
The closed-set assumption that only known classes can be classified during testing is usually adopted in traditional signal recognition missions. It has been thoroughly explored and made huge ...progress in the past decade. However, it cannot cope with the unknown categories coming from the changing environment. As waveform diversity technology evolves by leaps and bounds, the existence of novel unknown classes is inevitable in the open-world environment, imposing a huge challenge to the non-cooperative electronic support system. To further satisfy the demands of modern electronic intelligence systems and sense new threats, it is urgent to find an approach that can tackle unknown signals. An Open-Metric strategy is proposed in this article to deduce the unknown classes from the intercepted signals. By virtue of metric learning methods, a plain backbone can be trained to offer more discriminative representations and a consistent proxy for each class. According to extreme value analysis, information about known classes can be converted into an estimated score of unknown classes, creating an open decision layer. The investigated Open-Metric approach demonstrates its superiority in unknown signal inference tasks, facilitating improvements in the intelligence and smartness of the electronic reconnaissance agents to cope with future cognitive electronic warfare.
The current economic situation has highlighted the difficulties and fragility of some previous programmatic choices, which have strongly penalized Italian marginal areas. This has been further ...aggravated by the Ukrainian conflict and by the lengthening of the pandemic recession. Local planning has often proved to be unsustainable in the long-term due to its lack of global sustainability. Local projects are frequently developed and realized in situations of contingent needs, tight deadlines, and by below-strength staff, which do not allow for adequate and accurate overall planning. These difficulties have emerged and have particularly increased during the past year with the rising strain of responding promptly to the copious National and European funds released in support of the dual transition, established by the European Union. In this situation, it seems mandatory to support the marginal areas in their transition process and in their responsive and conscious participation in the allocated funding. The expectation is to finance projects with positive impacts and with long terms sustainable effects on the peripheral territories, increasing their competitiveness but mostly their socio-economic well- being. The aim of this study was to prioritize, through a multicriteria model, different projects in marginal areas according to their sustainability impact levels, in line with the European goals. This paper proposes an Absolute Analytic Hierarchy Process (AHP) model through a targeted selection of Urban Sustainability Indicators (USIs) to define the degree of sustainability of different urban projects. and their ranking in accordance with the National Recovery and Resilience Plan (NRRP) Missions. By examining the efficiency of the allocation of funds in maximizing the expected quantitative-qualitative impacts on marginal areas, this study allows to verify policy objectives. This paper may support future models able of ranking a large scale of urban projects on their sustainability impacts in marginal regions. The definition of scales of priorities can therefore become a useful tool capable of assisting territories in applying awareness to funds for projects with high sustainable impacts. L’attuale congiuntura economica negativa, aggravata dal conflitto ucraino e dal protrarsi della recessione pandemica, ha fatto emergere le difficoltà e le fragilità di alcune scelte programmatiche del passato che hanno penalizzato le aree interne del paese. Spesso l’attuazione e la pianificazione locale si è rivelata non sostenibile nel lungo termine, evidenziando la criticità di alcune scelte a scapito della sostenibilità globale di sistema. Frequentemente gli interventi locali vengono attuati in situazioni di necessità contingenti, scadenze già sollecitate, ed organici sottodimensionati, che non permettono una corretta e adeguata indagine programmatica e d’insieme. Tali complessità sono emerse e si sono acuite particolarmente durante quest’ultimo anno, alla luce della difficoltà di rispondere pronta- mente e strutturalmente agli innumerevoli bandi emanati su fondi nazionali ed europei per attuare la transizione duale in accordo con le direttive e gli obiettivi stabiliti dall’unione Europea. Supportare le aree in- terne nel loro processo di transizione e quindi nella loro partecipazione responsiva e consapevole ai finanziamenti stanziati, assume, quindi, un ruolo rilevante e di grande responsabilità. L’auspicio è che gli innumerevoli finanziamenti vengano direzionati da parte dei territori periferici verso progetti di impatto e con ricadute sostenibili nel lungo periodo, incrementando, non solo la loro competitività, ma anche, attraverso la loro efficacia, il proprio benessere socioeconomico. Lo scopo del presente studio è quello di definire, attraverso l’applicazione di un modello multicriteri, la scala di priorità di diverse progettualità sulle aree interne secondo criteri di sostenibilità, in coerenza con i goals europei. Il presente contributo propone, attraverso la selezione mirata di indicatori della sostenibilità urbana (USIs), un modello Analytic Hierarchy Process (AHP) assoluto in grado di definire il grado di sostenibilità e quindi di priorità dei progetti in coerenza con le missioni del Piano Nazionale di Ripresa e Resilienza (PNRR). Tale analisi permette di verificare gli obiettivi di policy, esaminando l’efficacia della ripartizione dei fondi per una massimizzazione quanti-qualitativa degli impatti attesi sul territorio. Tale lavoro è il punto di partenza per la creazione di modelli in grado di offrire una classificazione della sostenibilità di molteplici interventi urbani da attuare sulle aree marginali. La creazione di scale di priorità può quindi diventare uno strumento in grado di assistere i territori nell’accedere ai finanziamenti con una programmazione consapevole di impatto sostenibile.
Questo articolo analizza le forme di sfruttamento della manodopera indigena nelle campagne ecuadoriane e il loro inserimento nel nuovo sistema di diritto (1830 – 1906), tenendo conto della loro ...storia precoloniale e delle conseguenze sullo status giuridico dei contadini indigeni dalla colonia al primo decennio del XX secolo. In particolare, mette in rilievo l’influenza delle dinamiche sociali, economiche e politiche sulla legislazione emanata in materia indigena dalle autorità centrali e quella degli usi e costumi nell’applicazione della legge attraverso lo studio dell’istituto del concertaje.
Introduction and hypothesis
The objective of this study was to identify the predictors for persistent urodynamic stress incontinence (P-USI) in women following extensive pelvic reconstructive surgery ...(PRS) with and without midurethral sling (MUS).
Mmethods
A total of 1,017 women who underwent pelvic organ prolapse (POP) surgery from January 2005 to December 2013 in our institutions were analyzed. We included 349 USI women who had extensive PRS for POP stage III or more of whom 209 underwent concomitant MUS.
Results
Of the women who underwent extensive PRS without MUS, 64.3 % (90/140) developed P-USI compared to only 10.5 % (22/209) of those who had concomitant MUS. Those with concomitant MUS and PRS alone were at higher risk of developing P-USI if they had overt USI odds ratio (OR) 2.2, 95 % confidence interval (CI) 1.3–4.0,
p
= 0.014 and OR 4.7, 95 % CI 2.0–11.3,
p
< 0.001, respectively, maximum urethral closure pressure (MUCP) of < 60 cm H
2
O (OR 5.0, 95 % CI 3.0–8.1,
p
< 0.001 and OR 5.3, 95 % CI 2.7–10.4,
p
< 0.001, respectively), and functional urethral length (FUL) of < 2 cm (OR 5.4, 95 % CI 2.7–8.8,
p
< 0.001 and OR 3.9, 95 % CI 2.4–6.9,
p
< 0.001, respectively). Parity ≥ 6 (OR 3.9, 95 % CI 1.7–5.2,
p
< 0.001) and Prolift T (OR 3.1, 95 % CI 1.9–4,
p
< 0.001) posed a higher risk of P-USI in those with concomitant surgery. Perigee and Avaulta A seemed to be protective against P-USI in those without MUS.
Conclusions
Overt USI with advanced POP together with low MUCP and FUL values have a higher risk of developing P-USI. Therefore, counseling these women is worthwhile while considering the type of mesh used.
PDF
