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  • Limfocitne podvrste v kroničnih periapikalnih parodontitisih = Lymphocyte subpopulations in chronical periapical parodontitis
    Ihan Hren, Nataša, 1962-
    Background. Chronical periapical parodontitis (CPP) is the result of a pathological immune response to the continous stimuli from the inflammated dental pulp. CPP represents chronical focus of the ... inflammation.The purpose ofour study was to investigate CPP in sense off the immune response by flow cytometry (FC). Methods. 47 CPP samples were obtained after surgical removal-apicoectomy. Each CPP sample was examined by histological, bacteriological and flow cytometrical analysis of lymphocytes infiltrating CPPsamples. We used pathohistologic and microbiologic findings and compare them to the results of immunological analysis. Results. By FC we found a significant increase in proportions of Tlymphocytes expressing interleukin-2 receptors and ICAM 1 compared to peripheral blood lymphocytes. A decreased expression in proportions of cytotoxic Tlymphocytes (CD8) expressing interleukin-2 receptors and HLA DR molecules were found in CPP samples predominantly colonized by Streptococcus spp., compared with lesion predominantly colonized by strict anaerobes. Proportions of T helper cells that produce interferon-gama (INF-gama) was higher in CPP samples predominantly colonized by anaerobic bacteria. There were no differences in IL-4 expression by T cell in both groups (anaerobic and streptococcal). Among anaerobic CPP samples differences in proportion of T cells that express IL-2 receptors expression was also found between samples colonized by P. acnes and Bacteroides spp. Conclusions. Oral streptococci cause relatively limited tissue destruction and induce Th2 type of immune response accompained by non-cytotoxic inflammatory reaction. On the contrary, anaerobic bacteria induce Th 1 type of immune response that cause severe inflammatory reaction (type 4 of hypersensitivity) that damage the tissue by the action of cytotoxicT cell activation.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 2, 2000, str. 81-85)
    Type of material - article, component part
    Publish date - 2000
    Language - slovenian
    COBISS.SI-ID - 11185369

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