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In vitro characterization of the human skeletal stem cell-like properties of primary bone-derived mesenchymal stem /stromal cells in patients with late and early hip osteoarthritis [Elektronski vir]Jasenc, Lara, farmacevtka ...Human skeletal stem cells (hSSCs) were recently identified as podoplanin (PDPN)/CD73/CD164-positive and CD146-negative cells that decline with age, and play a role in the pathogenesis of ... osteoarthritis (OA). The aim of this study was to identify the hSSC-like properties of bone-derived mesenchymal stem/stromal cells (MSCs) of patients with late and early OA. Methods: First, we performed gene expression profiling for the hSSC markers in 32 patients with late and early OA, and donors without OA. Having identified the low expression of hSSC markers in late OA patients, we further performed trilineage differentiation and immunophenotyping for hSSC makers in the selected subsets from each donor group. Results: Our results show no differences in osteogenesis, chondrogenesis, and adipogenesis between the MSCs from the three groups. However, the immunophenotyping shows lower CD164 in MSCs from early OA patients in comparison with late and no OA subjects (p = 0.002 and p = 0.017). Conclusions: Our study shows that the in vitro hSSC-like properties of bone-derived MSCs are similar in patients with early and late OA, and in donors without OA. However, the lower percentage of CD164-positive MSCs in early OA patients indicates the potential of CD164 as a marker of the onset of OA.Source: Life [Elektronski vir]. - ISSN 2075-1729 (Vol. 12, iss. 6, art. 899, 2022, str. 1-15)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 112107267
Author | Jasenc, Lara, farmacevtka ... |
Title | In vitro characterization of the human skeletal stem cell-like properties of primary bone-derived mesenchymal stem /stromal cells in patients with late and early hip osteoarthritis [Elektronski vir] |
Publication date | 2022-05-07 |
COBISS.SI-ID | 112107267 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Mezenhimske matične celice-nosilci endogene regenerativne sposobnosti tkiv v boju proti staranju mišično-skeletnega sistema | J3-1749-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Napredna imunološka zdravila in celični pristopi v farmaciji | P1-0420-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://www.mdpi.com/2075-1729/12/6/899 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=140238 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jasenc, Lara, farmacevtka | |
Stražar, Klemen | 20414 |
Trebše, Rihard | 23524 |
Mihelič, Anže, kirurg | 50202 |
Mihalič, Rene | 33035 |
Jeras, Matjaž | 01302 |
Zupan, Janja, farmacevtka | 32306 |
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