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Semaglutid - prvi peroralni agonist receptorjev GLP-1 za zdravljenje sladkorne bolezni tipa 2 = Semaglutide - the first oral GLP-1 receptor agonist for the treatment of type 2 diabetesJovanović, Marija, farmacevtka ...Optimal glycemic control and multifactorial treatment are important for type 2 diabetes control. Non-pharmacological treatment is the mainstay of antihyperglycemic treatment, but it usually merits ... timely escalation of pharmacological intervention. One of the barriers to pharmacological treatment with GLP-1 receptor agonists was injectable treatment due to their polypeptide composition. In 2019, the first and only oral GLP-1 receptor agonist – semaglutide, was introduced to clinical use. Due to structural modifications and technological processing of the tablet, the molecule is resistant to degradation in the acidic gastric envi- ronment and has a comparable effect as in the form of injectable treatment. Oral semaglutide was effective in improving glycemic control and redu- cing body weight, and proven for its cardiovascular safety. The present article describes the mechanism of action of GLP-1 receptor agonists, the development of oral semaglutide, dosing instructions and data from studies of its efficacy and safety.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 73, št. 3, jul. 2022, str. 231-240)Type of material - article, component part ; adult, seriousPublish date - 2022Language - slovenianCOBISS.SI-ID - 114653443
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 73, št. 3, jul. 2022, str. 231-240)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jovanović, Marija, farmacevtka | ![]() |
Jančič, Eva, medicina | ![]() |
Janić, Miodrag | 33911 |
Janež, Andrej, 1971- | 18372 |
Lunder, Mojca, dr. med., 1980- | 28865 |
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