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The effect of lipophilicity of spin-labeled compounds on their distribution insolid lipid nanoparticle dispersions studied by electron paramagnetic resonanceAhlin Grabnar, Pegi ...Solid lipid nanoparticles (SLN) constitute an attractive drug carrier system. The aim of this study was to investigate the influence of lipophilicity and structure of different model molecules on ... their distribution in SLN dispersions. SLN composed of glyceryl tripalmitate as lipid and soybean lecithin and poloxamer 188 as stabilizers were prepared by a melt-emulsification process. PC(10,3), MeFASL(10,3), C14-Tempo, and Tempol were incorporated into SLN as spin-labeled compounds. The partition of SP between triglyceride and water was determined experimentally by electron paramagnetic resonance (EPR) and compared with calculated partition coefficients. The distribution of molecules in SLN dispersions was determined from the parameters of EPR spectra, from the reduction kinetics of the spin-labeled compounds with sodium ascorbate, and by computer simulation of EPR spectral line shapes. The experimentally obtained partition coefficients increase in the order Tempol < MeFASL(10,3) < C14-Tempo, showing the same trend as the partition coefficients calculated according to Rekker. In SLN dispersions, it was estimated that the ratio of SP between solid lipid core, phospholipid layers (deeper in SLN layer or in liposomes and closer to the surface of SLN), and water is for Tempol 0:0:100, for C14-Tempo 46:54(20:34):0, for MeFASL(10,3) 34:65(38:27):1, and for PC(10,3) 10:89(26:3:60):1.Source: Journal of pharmaceutical sciences. - ISSN 0022-3549 (vol. 92, no. 1, 2003, str. 58-66)Type of material - article, component partPublish date - 2003Language - englishCOBISS.SI-ID - 1245297
Author
Ahlin Grabnar, Pegi |
Kristl, Julijana |
Pečar, Slavko |
Štrancar, Janez |
Šentjurc, Marjeta
Topics
SLN |
EPR |
distribucija |
nanodelci
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ahlin Grabnar, Pegi | 15490 |
Kristl, Julijana | 09032 |
Pečar, Slavko | 03070 |
Štrancar, Janez | 18273 |
Šentjurc, Marjeta | 01119 |
Source: Personal bibliographies
and: SICRIS
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