Organic UV filters are ubiquitous as they are used in numerous personal care products. Consequently, people constantly come into direct or indirect contact with these chemicals. Albeit studies of the ...effects of UV filters on human health have been undertaken, their toxicological profiles are not complete. In this work, we investigated the immunomodulatory properties of eight UV filters representing different chemotypes, including benzophenone-1, benzophenone-3, ethylhexyl methoxycinnamate, octyldimethyl-para-aminobenzoic acid, octyl salate, butylmethoxydibenzoylmethane, 3-benzylidenecamphor, and 2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol. We demonstrated that none of these UV filters were cytotoxic to THP-1 cells at concentrations up to 50 μM. Importantly, our study highlighted the capacity of nontoxic concentrations of avobenzone and 3-benzylidene camphor to increase the secretion of interleukin 8 (IL-8) from both THP-1 cells and THP-1 derived macrophages. Further, they also exhibited a pronounced decrease of IL-6 and IL-10 release from lipopolysaccharide-stimulated peripheral blood mononuclear cells. The observed immune cell alterations suggest that exposure to 3-BC and BMDM could be involved in immune deregulation. Our research thus provided additional insight into UV filter safety profile.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
