-
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infectionBonotto, R. Milan ...The severity of the SARS-CoV-2 pandemic and the recurring (re)emergence of viruses prompted the development of new therapeutic approaches that target viral and host factors crucial for viral ... infection. Among them, host peptidases cathepsins B and L have been described as essential enzymes during SARS-CoV-2 entry. In this study, we evaluated the effect of potent selective cathepsin inhibitors as antiviral agents. We demonstrated that selective cathepsin B inhibitors, such as the antimicrobial agent nitroxoline and its derivatives, impair SARS-CoV-2 infection in vitro. Antiviral activity observed at early stage of virus entry was cell-type dependent and correlated well with the intracellular content and enzymatic function of cathepsins B or L. Furthermore, tested inhibitors were effective against the ancestral SARS-CoV-2 D614 as well as against the more recent BA.1_4 (Omicron). Taken together, our results highlight the important role of host cysteine cathepsin B in SARS-CoV-2 virus entry and show that cathepsin-specific inhibitors, such as nitroxoline and its derivatives, could be used to treat COVID-19. Finally, these results also suggest that nitroxoline has potential to be further explored as repurposed drug in antiviral therapy.Source: Antiviral research. - ISSN 0166-3542 (Vol. 216, 2023, 12 str.)Type of material - article, component part ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 156890115
Author
Bonotto, R. Milan |
Mitrović, Ana |
Sosič, Izidor |
Martinez-Orellana, Pamela |
Dattola, Federica |
Gobec, Stanislav, 1970- |
Kos, Janko, 1959- |
Marcello, Alessandro
Topics
SARS-CoV-2 |
COVID-19 |
coronavirus |
cathepsin |
nitroxoline |
drug repurposing |
inhibition |
koronavirus |
katepsin |
nitroksolin |
inhibicija |
ponovna uporaba zdravil
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Bonotto, R. Milan | |
Mitrović, Ana | 36440 |
Sosič, Izidor | 30816 |
Martinez-Orellana, Pamela | |
Dattola, Federica | |
Gobec, Stanislav, 1970- | 15284 |
Kos, Janko, 1959- | 04648 |
Marcello, Alessandro |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.