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  • Astrocytes are a key target for neurotropic viral infection [Elektronski vir]
    Potokar, Maja, 1973- ; Zorec, Robert, 1958- ; Jorgačevski, Jernej
    Astrocytes are increasingly recognized as important viral host cells in the central nervous system. These cells can produce relatively high quantities of new virions. In part, this can be attributed ... to the characteristics of astrocyte metabolism and its abundant and dynamic cytoskeleton network. Astrocytes are anatomically localized adjacent to interfaces between blood capillaries and brain parenchyma and between blood capillaries and brain ventricles. Moreover, astrocytes exhibit a larger membrane interface with the extracellular space than neurons. These properties, together with the expression of various and numerous viral entry receptors, a relatively high rate of endocytosis, and morphological plasticity of intracellular organelles, render astrocytes important target cells in neurotropic infections. In this review, we describe factors that mediate the high susceptibility of astrocytes to viral infection and replication, including the anatomic localization of astrocytes, morphology, expression of viral entry receptors, and various forms of autophagy.
    Source: Cells [Elektronski vir]. - ISSN 2073-4409 (Vol. 12, iss. 18, [article no.] 2307, 2023, str. 1-19)
    Type of material - e-article ; adult, serious
    Publish date - 2023
    Language - english
    COBISS.SI-ID - 165360387

    Link(s):

    https://www.mdpi.com/2073-4409/12/18/2307
    DOI

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