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A comparison of faster insulin aspart with standard insulin aspart using hybrid automated insulin delivery system in active children and adolescents with type 1 diabetes = a randomized double-blind crossover trialDovč, Klemen ...Objective: To evaluate the use of faster acting (FIA) and standard insulin aspart (SIA) with hybrid automated insulin delivery (AID) in active youth with type 1 diabetes. Research Design and Methods: ... In this double-blind multinational randomized crossover trial, 30 children and adolescents with type 1 diabetes (16 females; aged 15.0 – 1.7 years; baseline HbA1c 7.5% – 0.9% [58 – 9.8 mmol/mol]) underwent two unrestricted 4-week periods using hybrid AID with either FIA or SIA in random order. During both interventions, participants were using the hybrid AID (investigational version of MiniMed 780G; Medtronic). Participants were encouraged to exercise as frequently as possible, capturing physical activity with an activity monitor. The primary outcome was the percentage of sensor glucose time above range (180 mg/dL [10.0 mmol/L]) measured by continuous glucose monitoring. Results: In an intention-to-treat analysis, mean time above range was 31% – 15% at baseline, 19% – 6% during FIA use, and 20% – 6% during SIA use with no difference between treatments: mean difference = -0.9%; 95% CI: -2.4% to 0.6%; P = 0.23. Similarly, there was no difference in mean time in range (TIR) (78% and 77%) or median time below range (2.5% and 2.8%). Glycemic outcomes during exercise or postprandial periods were comparable for the two treatment arms. No severe hypoglycemia or diabetic ketoacidosis events occurred. Conclusions: FIA was not superior to SIA with hybrid AID system use in physically active children and adolescents with type 1 diabetes. Nonetheless, both insulin formulations enabled high overall TIR and low time above and below ranges, even during and after documented exercise.Source: Diabetes technology & therapeutics. - ISSN 1520-9156 (Vol. 25, iss. 9, 2023, str. 612-621)Type of material - article, component partPublish date - 2023Language - englishCOBISS.SI-ID - 167136771
Author
Dovč, Klemen |
Bergford, Simon |
Fröhlich-Reiterer, Elke |
Zaharieva, Dessi P. |
Potočnik, Nejka |
Müller, Alexander |
Lenarčič, Živa |
Calhoun, Peter |
Fritsch, Maria |
Sourij, Harald |
Bratina, Nataša, medicina, 1964- |
Kollman, Craig |
Battelino, Tadej
Topics
exercise |
faster acting insulin |
children |
adolescentes |
automated insulin delivery |
type 1 diabetes |
telesna vadba |
hitreje delujoči inzulin |
otroci |
mladostniki |
avtomatsko dovajanje inzulina |
diabetes, tip 1
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Dovč, Klemen | 34849 |
Bergford, Simon | ![]() |
Fröhlich-Reiterer, Elke | ![]() |
Zaharieva, Dessi P. | ![]() |
Potočnik, Nejka | 05201 |
Müller, Alexander | ![]() |
Lenarčič, Živa | ![]() |
Calhoun, Peter | ![]() |
Fritsch, Maria | ![]() |
Sourij, Harald | ![]() |
Bratina, Nataša, medicina, 1964- | 13409 |
Kollman, Craig | ![]() |
Battelino, Tadej | 13023 |
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