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Analiza literaturnih podatkov o absorpciji izbranih nesteroidnih protirevmatskih učinkovin iz transdermalnih farmacevtskih oblik in vivo ter in vitro = Analysis of literature data on the absorption of selected non-steroidal antirheumatic drugs from transdermal dosage forms in vivo and in vitro : enovit magistrski študij farmacijaŠtante, AmadejTransdermalna absorpcija je definirana kot prehajanje učinkovine skozi kožo v sistemski krvni obtok. Je zelo kompleksen proces, predvsem zaradi kompleksne zgradbe same kože. Zaradi vseh prednosti, ki ... jih ima transdermalna absorpcija, je potrebno spodbujati napredek tega področja. Posebej nas je zanimalo, kako so pridobljeni in kako so v literaturi prikazani podatki iz meritev in vitro ter iz študij in vivo prehajanja zdravilnih učinkovin skozi kožo. Zato smo v tej magistrski nalogi pregledali literaturo o transdermalni absorpciji treh nesteroidnih protirevmatskih učinkovin ibuprofena, ketoprofena in diklofenaka. Učinkovine so bile izbrane na podlagi dolgo poznane uporabe s transkutano aplikacijo. Članke smo iskali s pomočjo podatkovna baze Pubmed. Osredotočili smo se na članke, kjer so raziskovalci delali s človeškimi prostovoljci ali so uporabili človeško kožo. Vključene so bile tudi raziskave, kjer so bili uporabljeni živalski modeli ter umetne membrane. S pregledom relevantnih člankov obeh modelov, smo organizirali podatke o absorpciji in permeabilnosti izbranih nesteroidnih protirevmatikov, pridobljenih iz različnih modelov in metod. Ugotovili smo, da prihaja do velike variabilnosti in nedoslednosti v eksperimentalnih načrtih, zlasti pri izbiri metod in materialov v študijah in vitro. To je najbolj opazno pri uporabi sintetičnih membran, ki ne dajejo relevantnih rezultaov. Tudi študije in vivo na prostovoljcih so imele nekatere omejitve, kot so pomanjkanje uporabe neinvazivnih metod ter dolgotrajni postopki. Ugotovili smo, da bi za izboljšanje relevantnosti pridobljenih podatkov z vidika in vitro – in vivo korelacije bila v prihodnosti smiselna uporaba bolj standardiziranih metod in materialov za metodi in vitro in tudi in vivo. To bi korostilo njihovi uporabnosti v postopkih registracije in kontroli kakovosti končnih farmacevtskih oblik.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [A. Štante], 2023Language - slovenianCOBISS.SI-ID - 176388355
Author
Štante, Amadej
Other authors
Žakelj, Simon
Topics
Antirevmatiki |
korelacije |
transdermalna absorpcija |
nesteroidni antirevmatiki
Library | Call number – location, accession no. ... | Copy status |
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Faculty of Pharmacy, Lj. | Knjižnica emšf 615.2 ŠTANTE AMADEJ Analiza 1343 IN: 0017926 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Štante, Amadej | |
Žakelj, Simon | 22659 |
Source: Personal bibliographies
and: SICRIS
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