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Subkutano apliciranje monoklonskih protiteles [Elektronski vir] = Subcutaneous injection of monoclonal antibodies : pregled sestavin zdravil : review of medicine ingredientsePrašnikar, Monika ; Gašperlin, Mirjana ; Ahlin Grabnar, PegiRazvija se vse več bioloških zdravil, med katerimi prevladujejo zdravila z monoklonskimi protitelesi (angl. monoclonal antibodies, mAb), ki omogočajo specifično in učinkovito zdravljenje z manj ... neželenimi učinki. Zaradi kompleksne in občutljive proteinske zgradbe mAb je treba takšna zdravila vnašati parenteralno. Intravensko apliciranje, ki prevladuje, je lahko boleče, dolgotrajno in zahteva celo hospitalizacijo. Zato je vse več zdravil z mAb v razvoju namenjenih subkutani aplikaciji, ki je hitrejša, omogoča nižje stroške zdravljenja in boljše sodelovanje bolnikov. Subkutano pa lahko vbrizgamo le majhen volumen raztopine, zato so pogosto potrebne visoke koncentracije mAb, ki lahko povečajo viskoznost raztopin in povzročijo fizikalno nestabilnost molekul mAb v njih. Zdravila z mAb zato vsebujejo pufre, stabilizatorje in pomožne snovi za znižanje viskoznosti, ki prispevajo tudi k fizikalni stabilnosti mAb. Poleg teh sestavin članek predstavi tudi pomožne snovi, ki omogočajo vbrizgati večji volumen zdravila v podkožje in kombinacije terapevtskih mAb. Opisani so tudi inovativni sistemi za subkutano apliciranje mAb, kot so kompleksi, nanoklastri, suspenzije, mikrodelci in hidrogeli, ki so še v fazi razvijanja.Source: Zdravniški vestnik [Elektronski vir] : glasilo Slovenskega zdravniškega društva = Slovenian medical journal : Journal of Slovenian Medical Association. - ISSN 1581-0224 (Vol. 93, no. 1-2, 2024, str. 36-43)Type of material - e-article ; adult, seriousPublish date - 2024Language - slovenianCOBISS.SI-ID - 177454595
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| JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP | |
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| Database name | Field | Year |
|---|
| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
|---|---|
| Prašnikar, Monika | 56839 |
| Gašperlin, Mirjana | 11789 |
| Ahlin Grabnar, Pegi | 15490 |
Source: Personal bibliographies
and: SICRIS
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