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Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity [Elektronski vir]Aregay, Amare ...Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody ... and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and long-term outcome has been poorly investigated. In a cohort of thirty early tick-borne encephalitis (TBE) patients, we assessed the magnitude, specificity and functional properties of TBEV-specific T-cell and antibody responses. These responses early during disease were assessed in view of clinical manifestations, severity and long-term outcome. TBEV-specific T-cell responses to C, E, NS1, and NS5 proteins were significantly lower in patients with severe acute illness than in patients with mild TBE. Lower T-cell responses to E, NS1, and NS5 proteins also correlated with the development of meningoencephalomyelitis. Virus-specific antibody titres early after infection did not correlate with disease severity, clinical manifestations, or long-term outcome in this study, possibly due to the small number of patients of which matching serum and peripheral blood mononuclear cells were available. The findings suggest that virus-specific T cells afford a certain degree of protection against the development of severe TBEV-induced disease.Source: Emerging microbes & infections. - ISSN 2222-1751 (Vol. 13, iss. 1, [article no.] 2317909, 2024, str. 1-10)Type of material - e-articlePublish date - 2024Language - englishCOBISS.SI-ID - 189011971
Author
Aregay, Amare |
Slunečko, Jan, 1997- |
Bogovič, Petra |
Korva, Miša |
Resman Rus, Katarina |
Knap, Nataša, 1978- |
Beicht, Jana |
Kubinski, Mareike |
Saletti, Giulietta |
Steffen, Imke |
Strle, Franc, 1949- |
Avšič-Županc, Tatjana
Topics
TBEV |
tick-borne encephalitis (TBE) |
TBEV-specific T-cells |
disease severity |
outcome |
TBEV |
klopni encefalitis |
TBEV-specifične T-celice |
raznolikost bolezni |
izid
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Aregay, Amare | ![]() |
Slunečko, Jan, 1997- | 55839 |
Bogovič, Petra | 27886 |
Korva, Miša | 30696 |
Resman Rus, Katarina | 35044 |
Knap, Nataša, 1978- | 28601 |
Beicht, Jana | ![]() |
Kubinski, Mareike | ![]() |
Saletti, Giulietta | ![]() |
Steffen, Imke | ![]() |
Strle, Franc, 1949- | 13301 |
Avšič-Županc, Tatjana | 10331 |
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