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Slope between positive and negative ERG components in patients with open-angle glaucoma [Elektronski vir]Šuštar Habjan, Maja, 1979- ; Cvenkel, BarbaraPurpose: To evaluate ERG morphology, in particular the slope between P50 and N95 components of the PERG, as well as between the b-wave and the photopic negative response (PhNR) of the light-adapted ... (LA) ERG in patients with retinal ganglion cell (RGC) dysfunction due to open-angle glaucoma. Methods: The PERG and LA-ERG traces of 16 glaucoma patients and 21 age-similar controls were retrospectively analysed. The ERG signal between the peak of the positive component (P50 and b-wave) towards the negative component (N95 and PhNR) was described by a linear regression y = a + bx, where the parameter b indicated the steepness of the P50-N95 and b-PhNR slope. Results: The P50-N95 slope was less steep in glaucoma patients (-0.079 ± 0.034 vs. -0.166 ± 0.050 in controls, p < 0.001), while the b-PhNR slope was not affected (-4.2 ± 2.1 vs. -4.4 ± 1.2, p = NS). The P50-N95 slope showed strong correlation with PhNR and N95 amplitude (r = -0.68 and -0.92, respectively; p < 0.001), while the b-PhNR slope correlated only with b-wave amplitude (r = -0.66, p < 0.001). Conclusions: The P50-N95 slope is a sensitive indicator of RGC dysfunction in patients with open-angle glaucoma. A similar component of LA-ERG, the b-PhNR slope, is less affected by glaucomatous RGC dysfunction and probably originates from similar retinal mechanisms as the b-wave.Source: Documenta ophthalmologica. - ISSN 1573-2622 (Vol. 149, iss. 1, 2024, str. 53-59)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 195133187
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Šuštar Habjan, Maja, 1979- | 25616 |
Cvenkel, Barbara | 21069 |
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