Antifosfolipidna protitelesa pri trombozi, aterosklerozi in hipertenziji : magistrska naloga
Čučnik, Saša
Antiphospholipid antibodies (aPL) are a heterogeneous family of antibodies associated with arterial and venous thromboses and recurrent foetal loss. The presence of at least one of the ...above-mentioned clinical manifestations together with the increased level of aPL in the blood is termed the antiphospholipid syndrome (APS). It can occur as a primary - independent syndrome or as a secondary APS - together with some other autoimmune disease, most commonly systemic lupus erythematosus (SLE). It is believed that aPL havea pathogenic role in the development of APS. For their binding to anionic phospholipids plasma proteins are needed among which the beta-2-glycoprotein I(beta2-GPl) has been the most important and also most widely researched. However, aPL are transiently also present in some infectious diseases without increasing the risk of thromboses and without the need of cofactors for binding to anionic phospholipids. aPL are determined with phospholipid dependent coagulation tests and with enzyme linked immunosorbent assays (ELISA). By different performances of ELISA it is possible to determine aPL ofdifferent specificities and thus differentiate the pathogenic aPL from non-pathogenic ones. Since no anti-beta2-GPl ELISA has yet been standardised, we performed a standardisation on a large number of sera from healthy persons.The cut-off values for IgG, IgM and IgA anti-beta2-GPl were determinedand expressed also in concentrations of monoclonal antibodies (MoAb)and appropriate dilutions of internal standards (IS). By expressing the cut-off values in concentrations of MoAb, more effective comparison was thus rendered possible among results obtained in different laboratories. Several authors have claimed that the occurrence of aPL might be the cause of thromboses and recurrent foetal loss in patients with autoimmune diseases. (Abstract truncated at 2000 characters.)
Type of material - master's thesis
Publication and manufacture - Ljubljana : [S. Čučnik], 2000
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