Vpliv tangencialnega toka plazme na raztapljanje krvnih strdkov
Štrukelj, Mitja
Lysis of occlusive thrombi initially proceeds via penetrating channels that reacanalize the occluded vessel, but does not result in complete dissolution of the clot. When the first reperfusion ...channel pierces the clot, blood startsflowing through the channel and further blood clot lysis proceeds from the borders of the channel into the direction of the remaining clot. It has not been known whether tangential flow of blood plasma along the clot causes exchange of the serum inside the clot by diffusion aione or also by convectiveexchange when the tangentiai flow is turbulent. Our aim was to test on an in vitro model system how non-occlusive whole blood clots were dissolvedby tangential flow of plasma, that contained either fibrin-specific tissue plasminogen activator (t-PA) at 2 micro gžml, or fibrin non-specific streptokinase at 250 IUžml. The respective concentrations of t-PA and streptokinase were chosen to represent the average therapeutic concentrations during thrombolytic treatrnent of myocardiai infarction. Cylindrical clots with a diameter of 3 mm and length of 3 cm were formed in glass tubes and pierced lengthwise by a needle with a diameter of 0.7 mm. The nonocclusive clots were connected to a perfusion system. The velocity of plasma f(owing through the preformed channel in the clot was initialiy 426 +-13 cmžs and fellto 86 +- 3 cmžs (n = 5) after complete clot dissolution. Magnetic resonance imaging of transverse clot sections was used for measuring the transport of p(asma, containing the contrast agent Gd-DTPA, from the flow channe( into the clot. Simultaneously, clot dissolution was measured. Penetration of contrast agent-containing plasma into clots did not depend on the choice of thrombolytic agent. (Abstract truncated at 2000 characters).
Type of material - research report
Publication and manufacture - Ljubljana : [M. Štrukelj], 2000
Prešernove naloge ŠTRUKELJ Mitja Vpliv IN: 020010374
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