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Coalescence of phospholipid membranes as a possible origin of anticoagulant effect of serum proteinsUrbanija, Jasna ...Interactions between phospholipid membranes (made of palmitoyloleoylphosphatidylcholine, cardiolipin and cholesterol) after addition of beta2 glycoprotein I (beta2GPI) or anti-beta2GPI antibodies or ... a mixture of both were studied by observing giant phospholipid vesicles under the phase contrast microscope. Both, negatively charged and neutral vesicles coalesced into complexes and adhered to the bottom of the observation chamber in the presence of beta2GPI in solution. Anti-beta2GPIs alone or previously mixed with beta2GPI caused coalescence of charged but not neutral vesicles, i.e. for neutral membranes the effect of beta2GPI was abolished by the presence of anti-beta2GPIs. Since the presence of the above adhesion mediatorscan prevent fragmentation of the membrane we propose a (new) possibleanticoagulant mechanism for some serum proteins by preventing the release of prothrombogenic microexovesicles into circulation.Source: Chemistry and physics of lipids. - ISSN 0009-3084 (Vol. 150, no. 1, 2007, str. 49-57)Type of material - article, component part ; adult, seriousPublish date - 2007Language - englishCOBISS.SI-ID - 23283161
Author
Urbanija, Jasna |
Tomšič, Nejc |
Lokar, Maruša |
Ambrožič, Aleš, 1966- |
Čučnik, Saša |
Rozman, Blaž, 1944- |
Kandušer, Maša |
Iglič, Aleš, 1960- |
Kralj-Iglič, Veronika
Topics
Anticoagulants |
Membranes, Artificial |
Glycoproteins |
Apolipoproteins |
Cardiolipins |
Mice, Inbred Balb C |
Phospholipids |
IgG |
Antibodies, Monoclonal |
Antiphospholipid Syndrome |
Microscopy, Phase-Contrast |
Antikoagulansi |
Apolipoproteini |
Glikoproteini |
Kardiolipini |
Membrane umetne |
Antifosfolipidni sindrom |
Fosfolipidi |
IgG |
Mikroskopija faznokontrastna |
Miši seva BALB C |
Protitelesa monoklonska |
antikoagulant |
mikropartikli |
anticoagulant |
microparticles
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Urbanija, Jasna | 27568 |
Tomšič, Nejc | |
Lokar, Maruša | 27526 |
Ambrožič, Aleš, 1966- | 19209 |
Čučnik, Saša | 16362 |
Rozman, Blaž, 1944- | 07180 |
Kandušer, Maša | 18619 |
Iglič, Aleš, 1960- | 04634 |
Kralj-Iglič, Veronika | 05916 |
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