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Metabolic and cardiovascular changes in women with polycystic ovary syndromeMeden-Vrtovec, Helena ; Vrtovec, Bojan, 1972- ; Osredkar, Joško, 1955-Objective: To analyze the relationship between QTc interval and cardiovascularrisk factors in women with polycystic ovary syndrome (PCOS). Methods: Study group included 119 PCOS women (age: ... 32.2+/-5.2 years) and the control group 64 age-matched healthy women; they all underwent QT interval measurement, and plasma levels of high-sensitivity CRP (hsCRP), endothelin-1 (ET1), insulin, and testosterone determinations. Results: In PCOS women hsCRP (2.35+/-2.14 mg/L vs. 1.01+/-1.28 mg/L; P=0.04), ET1 (23.6+/-10.3 ng/L vs. 7.7+/-15.9 ng/L; P=0.01), and insulin (16.5+/-7.8 mIU/L vs. 11.8+/-10.7 mIU/L;P=0.03) levels were significantly higher, and QTc interval significantlyshorter than in controls (401+/-61 ms vs. 467+/-61 ms; P=0.007). In 67 (56%) PCOS patients with a short QTc interval (<400 ms), plasma testosterone levels were significantly higher than in PCOS women with normal QTc interval (2.3+/-2.1 nmol/L vs. 1.4+/-1.7 nmol/L; P=0.02). Conclusion: In patients with polycystic ovary syndrome increased testosterone levels may attenuate the effects of coronary risk factors.Source: International journal of gynaecology & obstetrics. - ISSN 0020-7292 (Letn. 99, št. 2, 2007, str. 87-90)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 23367385
Author
Meden-Vrtovec, Helena |
Vrtovec, Bojan, 1972- |
Osredkar, Joško, 1955-
Topics
Polycystic Ovary Syndrome |
Electrocardiography |
C-Reactive Protein |
Endothelin-1 |
Insulin |
Adult |
Testosterone |
Coronary Disease |
Risk Factors |
C-reaktivna beljakovina |
Elektrokardiografija |
Endotelin-1 |
Inzulin |
Policistični jajčnik, sindrom |
Dejavniki tveganja |
Koronarna bolezen |
Odrasli |
Testosteron
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source: International journal of gynaecology & obstetrics. - ISSN 0020-7292 (Letn. 99, št. 2, 2007, str. 87-90)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Meden-Vrtovec, Helena | 08772 |
Vrtovec, Bojan, 1972- | 18826 |
Osredkar, Joško, 1955- | 10691 |
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