-
Cytokine concentrations in basal cell carcinomas of different histological types and localizationElamin, Issa ...Background: Basal cell carcinoma (BCC) is the most common malignant skin tumor. Cytokines as major mediators of the immune system have been shown to play an important role in biology of the neoplasm ... with the general predomination of Th2 cytokines, whereas IFN-gamma and other Th1 cytokines are prevalent in spontaneously regressing tumors. Objective: We were interested incomparing cytokine levels in BCC and cutaneous squamous cell tumors with BCCof different localization and histological subtypes. Material and methods: Explants from freshly excised BCC from 18 patients, and cutaneous squamous cell tumors (solar keratoses and Bowenćs disease) from 9 patients were cultivated for 24 h. Cytokine (IL-2, IFN-gamma, IL-4, IL-5, IL-6, IL-8, IL-10,IL-12, TNFalpha, IL-1beta) concentrations in culture supernatants were determined by a sandwich immunoassay. Results: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of squamous cell tumors. Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in tumors localized to the head and neck compared to those on the trunk or extremities. Interleukin-6 concentrations were higher in aggressive BCC variants (infiltrative and micronodular), but the difference was not statistically significant (p = 0.068). Conclusions: Confirming the earlier findings that BCCis a tumor with a Th2 cytokine microenvironment, this study further shows that BCC situated on the head and neck produce even more of certain Th2 cytokines (IL-4 and IL-5) and TNF-alpha, a crucial immunosuppressive cytokine released upon UVB irradiation.Source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 17, št. 2, 2008, str. 55-59)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24540121
Author
Elamin, Issa |
Zečević, Radoš |
Vojvodić, Danilo |
Medenica, Ljiljana |
Pavlović, Miloš, 1966-
Topics
Skin Neoplasms |
Carcinoma, Basal Cell |
Cytokines |
Tumor Necrosis Factor |
Interleukin-4 |
Interleukin-5 |
Interleukin-2 |
Interleukin-6 |
Interleukin-8 |
Interleukin-10 |
Interleukin-12 |
Interleukin-1 |
Kožne novotvorbe |
Tumor nekrotizirajoči faktor |
Citokini |
Karcinom bazalnocelični |
Interlevkin-4 |
Interlevkin-6 |
Interlevkin-5 |
Interlevkin-8 |
Interlevkin-1 |
Interlevkin-2 |
Interlevkin-10 |
Interlevkin-12
source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 17, št. 2, 2008, str. 55-59)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Elamin, Issa | |
Zečević, Radoš | |
Vojvodić, Danilo | |
Medenica, Ljiljana | |
Pavlović, Miloš, 1966- | 30480 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.