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Molecular-imaging probe 2-(1-{6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile labels prion plaques in vitroBresjanac, Mara ...The study aimed to evaluate the fluorescent molecular-imaging probe 2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)mal ononitrile (FDDNP) for its ability to selectively and reproducibly ... label prion plaques infixed, paraffin-embedded cerebellar sections from patients of confirmed Gerstmann-Straussler-Scheinker disease, sporadic Creutzfeldt-Jacob disease (CJD) with kuru plaques, and variant CJD (vCJD). FDDNP is a highly hydrophobic, viscosity-sensitive, solvent-sensitive, fluorescent substance, whose radiofluorinated analog (18F)FDDNP has recently been successfully used to label senile plaques and neurofibrillary tangles in the living brain of Alzheimer's disease patients with positron emission tomography. Our results show that FDDNP reliably identifies all prion plaques, including small cluster-plaques in vCJD. This finding may open new in vivo diagnostic possibilities for vCJD.Source: The Journal of neuroscience. - ISSN 0270-6474 (Vol. 23, no. 22, 2003, str. 8029-8033)Type of material - article, component partPublish date - 2003Language - englishCOBISS.SI-ID - 25366789
Author
Bresjanac, Mara |
Šmid, Lojze, M. |
Vovko, Tomaž |
Petrič, Andrej |
Barrio, Jorge R. |
Popović, Mara
Topics
medicina |
organska kemija |
nevrologija |
živčevje |
živci |
različice Creutzfeld-Jacob-sove bolezni |
CJD |
flourescenčna mikroskopija |
fluorescenčno označevanje |
TSE |
amiloid |
derivati FDDNP |
analogi |
prioni |
človek |
flourescent labeling |
human |
neuroimaging |
TSE |
variant Creutzfeldt-Jacob disease |
amyloid
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bresjanac, Mara | 10428 |
Šmid, Lojze, M. | 36541 |
Vovko, Tomaž | 30546 |
Petrič, Andrej | 05044 |
Barrio, Jorge R. | ![]() |
Popović, Mara | 07090 |
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