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  • Diagnoza in zdravljenje akutne hiperamoniemije = Diagnosis and early management of acute hyperammonaemia
    Žerjav-Tanšek, Mojca ; Bratanič, Nevenka ; Battelino, Tadej
    Acute hyperammonaemia is a consequence of inborn defects of urea cycle or acute liver damage. Clinical presentation varies considerably with the age of the aff ected individual and includes nausea, ... vomiting, neuropsychiatric symptoms, convulsions and progressive lethargy with a deepening coma. Ammonia concentration above 200 microM is a medical emergency and requires prompt treatment, regardless of its aetiology. The acute management includes restriction of protein intake, glucose infusion suffi cient to maintain anabolic state, administration of ammonia scavengers (sodium benzoate, sodium phenylacetate, sodium phenylbutyrate), administration of urea cycle substratesand haemodialysis when the concentration of ammonia is exceedingly high or does not respond promptly to the medical treatment. Elevated ammonia concentration is neurotoxic and causes irreversible glial and neuronal damage resulting in cerebral oedema with poor outcome. Early diagnosis and prompt treatment are crucial and may considerably improve the clinical course.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, št. 2, 2010, str. 164-172)
    Type of material - article, component part
    Publish date - 2010
    Language - slovenian
    COBISS.SI-ID - 26740441

    Link(s):

    http://szd.si/user_files/vsebina/Zdravniski_Vestnik/2010/februar/164-172.pdf
    Digitalna knjižnica Slovenije - dLib.si

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