Učinek fermentiranega mleka v hrani poskusnih živali na pojavnost eksperimentalnih črevesnih tumorjev = Effects of fermented milk on chemically induced colorectal epithelial tumors in rats : doktorska disertacija
Hlastan-Ribič, Cirila
Introduction: Colorectal carcinoma (CRC) is one of the most frequently observed malignarn tumors in the developed countries of the world. Several studies have demonstrated a significant influence of ...nutrition in the prevention of CRC incidence. Some experimental data are available on the inhibitory role of fermented milk on the development of CRC. On the other hand, epidemiological data are very diverse. There are no data available on the effects of fermented milk products containing different levels of fat on the development of CRC. Epidemiologic and a few other studies indicate a certain relation between fat consumption and different kinds of cancer. Several studies indicate relation between fat consumption and development of CRC. The aim of the study was to determine the effect of kefir (with differentfat levels) and milk on the incidence of experimentally induced colorectal epithelial tumors (CET). Methods and materialČ Our hypothesis was tested using the animal experimental model. We used 120 ten-week old male Wistar rats. The animals were randomly distributed into four groups, 30 rats in each group. Groups were formed according to the feeding regimeČ three experimental and one control group. For the induction of intestinal tumors, weused 1.2 dimethylhydrazine (DMH). All groups received standard pellets for rodents and tap water ad lihitum. In addition to the standard feeding regime, the first experimental group received kefir containing 3.5% milk fat ad libitum. The second group received kefir with 1.1 % milk fat and the third group received sterilized milk with l.l% milk fat. The consumption of kefir and nilk, respectively, was the same in all three groups. (Abstract truncated at 2000 characters)
Type of material - dissertation
Publication and manufacture - Ljubljana : [C. Hlastan Ribič], 2005
doktorske disertacije HLASTAN RIBIČ C. Učinek IN: 020050577
available - outside loan, loan period: 1 months
MF, Central Medical Library, Lj.
doktorske disertacije HLASTAN RIBIČ C. Učinek IN: 020050578
available - outside loan, loan period: 1 months
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