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Association between 11ß-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian populationDujić, Tanja ...Introduction: The enzyme 11Ž-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) catalyzes the conversion of the hormonally inactive cortisone to active cortisol, thus facilitating glucocorticoid receptor ... activation in target tissues. Increased expression of 11Ž-HSD1 in adipose tissue has been associated with obesity and insulin resistance. In this study, we investigated the association of two 11ß-HSD1 gene (HSD11B1) polymorphisms with the metabolic syndrome (MetS) and its characteristics in the Bosnian population. Materials and methods: The study included 86 participants: 43 patients diagnosed with MetS and 43 healthy controls. Subjects were genotyped for two HSD11B1 gene polymorphisms: rs846910: G>A and rs45487298: insA, by the high resolution melting curve analysis. Genotype distribution and an infl uence of genotypes on clinical and biochemical parameters were assessed. Results: There was no significant difference in the mutated allele frequencies for the two HSD11B1 gene polymorphisms between MetS patients and controls. In MetS patients, no signifi cant associations between disease-associated traits and rs45487298: insA were found. Regarding rs846910:G>A variant, heterozygous patients (G/A) had signifi cantly lower systolic (P = 0.017) and diastolic blood pressure (P = 0.015), lower HOMA-IR index (P = 0.011) and higher LDL-cholesterol levels (P = 0.049), compared to the wild-type homozygotes. In the control group, rs45487298: insA polymorphism was associated with lower fasting plasma insulin levels (P = 0.041), lower homeostasis model assessment insulin resistance (HOMA-IR) index (P = 0.041) and lower diastolic blood pressure (P = 0.048). Signifi cant diff erences between rs846910: G>A genotypes in controls were not detected. Haplotype analysis confi rmed the association of rs45487298: insA with markers of insulin resistance in the control subjects. Conclusions: Our results indicate that a common rs45487298: insA polymorphism in HSD11B1 gene may have a protective eff ect against insulin resistance.Source: Biochemia medica : glasnik Hrvatskoga društva medicinskih biokemičara. - ISSN 1330-0962 (Vol. 22, no. 1, 2012, str. 76-85)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 3200113
source: Biochemia medica : glasnik Hrvatskoga društva medicinskih biokemičara. - ISSN 1330-0962 (Vol. 22, no. 1, 2012, str. 76-85)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Dujić, Tanja | |
Bego, T. | |
Mlinar, Barbara, 1974- | 18996 |
Semiz, Sabina | |
Malenica, M., biokemik, farmacevt | |
Prnjavorac, Besim | |
Ostanek, Barbara, 1972- | 18154 |
Marc, Janja | 12189 |
Čaušević, Adlija |
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