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Screening of phenolic compounds reveals inhibitory activity of nordihydroguaiaretic acid against three enzymes involved in the regulation of blood glucose levelRoškar, Irena, 1985- ; Štrukelj, Borut ; Lunder, Mojca, 1977-In this work we have focused on the inhibition of three different enzymes with a role in postprandial glucose management: alpha-amylase, alpha-glucosidase and dipeptidyl peptidase 4. The assortment ... of 29 monomeric phenolic compounds was first screened at a single concentration. Next, the IC50 values of tested compounds were evaluated for compounds that considerably inhibited any of the enzymes. Nordihydroguaiaretic acid, a phenolic compound abundant in Creosote bush Larrea tridentata, possessed inhibitory activity for all tested enzymes. This in vitro mechanism of action supports traditional use of Creosote bush in diabetes treatment.Source: Plant foods for human nutrition. - ISSN 0921-9668 (Vol. 71, iss. 1, 2016, str. 88-89)Type of material - article, component partPublish date - 2016Language - englishCOBISS.SI-ID - 4028273
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http://link.springer.com/article/10.1007%2Fs11130-016-0530-0Dostop preko računalnikov UL
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Roškar, Irena, 1985- | 36281 |
Štrukelj, Borut | 07849 |
Lunder, Mojca, 1977- | 25096 |
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