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Vgrajevanje salicilne kisline v alginatne mikrosfere z ekstruzijo curka tekočine = Incorporation of salicylic acid into alginate microspheres by liquid extrusion : univerzitetni študijski program KozmetologijaKrampelj, BetkaZ metodo ekstruzije curka tekočine z vibrirajočo membrano smo pripravili alginatne mikrosfere s salicilno kislino. Z dodatkom Tweena 80 ali laktoze v alginatno raztopino za iztiskanje ali dodatkom ... hitosana v raztopino za premreževanje s CaCl2 smo spreminjali lastnosti mikrosfer in s tem želeli vplivati na hitrost sproščanja aktivne kozmetične sestavine. Med sušenjem se je premer izdelanih mikrosfer bistveno zmanjšal. Posušeni delci so bili v vseh primerih manjši od 1000 mikro m. Največji premer so imeli delci s hitosanom, ki so se med sušenjem tudi najbolj sprijeli. Največ salicilne kisline se je vgradilo v delce brez dodatkov, pri katerih je bil delež raztopine alginata za injiciranje višji (2,0 %) kot pri serijah s Tweenom 80 in z laktozo (1,8 %). Z dodatkom hitosana v raztopino za premreževanje se vgrajevanje salicilne kisline v mikrodelce ni povečalo. Profil sproščanja aktivne kozmetične sestavine je pokazal, da se iz mikrosfer ni sprostila vsa vgrajena salicilna kislina, najverjetneje, ker se alginatno ogrodje ni v celoti raztopilo. Po 5 minutah raztapljanja mikrosfer v vodi se je sprostila večina salicilne kisline iz vseh mikrosfer, kar pomeni, da nismo uspeli upočasniti njenega sproščanja. Največ salicilne kisline se je sprostilo iz mikrosfer brez dodatkov, najmanj pa iz mikrosfer z laktozo. Tween 80 ni pospešil sproščanja salicilne kisline iz mikrosferType of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [B. Krampelj], 2019Language - slovenianCOBISS.SI-ID - 4783985
Author
Krampelj, Betka
Other authors
Planinšek, Odon
Topics
Farmacevtska tehnologija |
Sušenje |
ekstruzija curka tekočine |
vibrirajoča membrana |
alginatne mikrosfere |
salicilna kislina |
hitosan
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Library | Call number – location, accession no. ... | Copy status |
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Faculty of Pharmacy, Lj. | Knjižnica UNK 66.02 KRAMPELJ BETKA Vgrajevanje 175 IN: 0016291 |
available - reading room |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Krampelj, Betka | ![]() |
Planinšek, Odon | 14935 |
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