-
An impaired glucagon-like peptide-1 response is associated with prediabetes in polycystic ovary syndrome with obesityFerjan, Simona ...Objective Impaired glucose homeostasis in polycystic ovary syndrome (PCOS) is associated with obesity, age, and disease phenotype. This study aimed to investigate the glucagon-like peptide-1 (GLP-1) ... response in patients with obesity and PCOS with normal glucose tolerance (NGT) or prediabetes. Methods Twenty-six women with obesity and PCOS were included. Thirteen women had NGT and 13 had prediabetes. Serum glucose, insulin, and GLP-1 levels were measured during an oral glucose tolerance test. Beta-cell function and insulin resistance were determined. Results Women with prediabetes had significantly lower GLP-1 levels than did those with NGT after a glucose load. GLP-1 levels <3.02%pM at 120 minutes were associated with prediabetes. Women with prediabetes had a lower oral glucose insulin sensitivity (OGIS) index and greater amount of visceral adipose tissue than did those with NGT. Plasma GLP-1 levels at 120 minutes were correlated with visceral adiposity and the OGIS index. A change in GLP-1 levels was correlated with a family history of type 2 diabetes. Conclusion The GLP-1 response is lower in patients with obesity, PCOS, and prediabetes than in those with obesity, PCOS, and NGT. Further investigation of the GLP-1 response as a potential separate risk factor for prediabetes in PCOS is required.Source: Journal of international medical research. - ISSN 0300-0605 (Vol. 47, iss. 10, 2019, str. 4691-4700)Type of material - article, component part ; adult, seriousPublish date - 2019Language - englishCOBISS.SI-ID - 4810865
Author
Ferjan, Simona |
Jensterle Sever, Mojca, 1979- |
Oblak, Tjaša, zdravnica |
Prodan Žitnik, Irena |
Marc, Janja |
Goričar, Katja, 1987- |
Dolžan, Vita |
Janež, Andrej, 1971-
Topics
Debelost |
Sindrom policističnega ovarija |
Diabetes |
prediabetes |
obesity |
polycistic ovary syndrome |
glucagon-like peptide-1 (GLP-1) response |
normal glucose tolerance |
insulin
![loading ... loading ...](themes/default/img/ajax-loading.gif)
source: Journal of international medical research. - ISSN 0300-0605 (Vol. 47, iss. 10, 2019, str. 4691-4700)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Ferjan, Simona | 50053 |
Jensterle Sever, Mojca, 1979- | 32347 |
Oblak, Tjaša, zdravnica | 51414 |
Prodan Žitnik, Irena | 22657 |
Marc, Janja | 12189 |
Goričar, Katja, 1987- | 33110 |
Dolžan, Vita | 11711 |
Janež, Andrej, 1971- | 18372 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.