The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin▫$alpha_vbeta_3$▫)-mediated cell adhesion of human umbilical vein endothelial cells
Kenda, Maša, farmacevtka ...
Endocrine disrupting chemicals (EDCs) are associated with cancer development and progression due to their promotion of increased cell invasiveness and metastasis formation. However, the effects of ...EDCs on cell adhesion mediated through integrins have not been well studied to date. Their actions are implicated by binding sites for hormones on the vitronectin receptor (VTNR; or integrin [alpha[sub]v[beta][sub]3), which is involved in tumor angiogenesis and metastasis. VTNR-expressing human umbilical vein endothelial cells (HUVECs) were used to determine the effects of EDCs and endogenous hormones on cell adhesion to vitronectin-coated surfaces, and on VTNR activation. Cell adhesion was significantly increased for bisphenol A, triclocarban, and triclosan (10, 100nM; p<0.05), with similar trends for bisphenols AF and S (10, 100nM; p>0.05). No changes in cell adhesion were seen for 5alpha]-dihydrotestosterone, 17[beta]-estradiol, triiodothyronine, imatinib and paroxetine. These data indicate that EDC-mediated increases in HUVEC adhesion to vitronectin are not mediated through androgenic, estrogenic, or thyroid activities, nor through activation of VTNR. Although these effects of EDCs on HUVEC adhesion require further investigation of the underlying mechanism(s) of action to define their biological relevance, the low-dose effects and nonmonotonic responses revealed here define the need for further investigation of these EDCs.
The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin▫$alpha_vbeta_3$▫)-mediated cell adhesion of human umbilical vein endothelial cells
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2022-03-11
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85860099
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Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin
P1-0208-2015
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Farmacevtska biotehnologija: znanost za zdravje
P4-0127-2019
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
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https://www.sciencedirect.com/science/article/pii/S0887233321002009
