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  • Urotelijske celice sečnega mehurja miši med eksperimentalno ishemijo : magistrsko delo
    Korošec, Peter, 1970-
    An ischemic in vivo model of urinary bladder was developed to study early molecular and ultrastructural changes of the mice urothelium. THe urothelium rnse to short-term experimental ischemia (30 to ... 120 minutes) was investigated by light, fluorescence and electron microscopy using immunocytochemistral and histochemistral methods as well as by flouremetric measurement of the (Ca2+)i.It was established that ischemic alterations are focally distributed and expressed by desquamation of all strata of the urothelium. Urothelium damages occur as funnels formed wounds extending to the basal cells. The damages are proportional to the duration of ischemia, contraction effect in vivo and in vivo induced reperfusion. Ischemia causes a disruption of the celljunctions and consequently the blood urine barrier. These changes are related to the increased (Ca2+)i and alternation of actin cytoskeleton. Exposal of desquamated live cells to the hypertonic and toxic urine gradually leads to irreversible changes.
    Type of material - master's thesis
    Publication and manufacture - Ljubljana : [P. Korošec], 1998
    Language - slovenian
    COBISS.SI-ID - 9348057

Library Call number – location, accession no. ... Copy status
National Institute of Biology and BF, Department of Biology, Ljubljana BF oddelek za biologijo
mg 61 KOROŠEC P. Urotelijske
IN: 0032115 		available - reading room
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