Road traffic noise in urban areas is a major source of annoyance. A quiet façade has been hypothesized to beneficially affect annoyance. However, only a limited number of studies investigated this hypothesis, and further quantification is needed. This study investigates the effect of a relatively quiet façade on the annoyance response. Logistic regression was performed in a large population based study (GLOBE, N~18,000), to study the association between road traffic noise exposure at the most exposed dwelling façade (L(den)) and annoyance in: (1) The subgroup with a relatively quiet façade (large difference in road traffic noise level between most and least exposed façade (Q>10 dB); (2) the subgroup without a relatively quiet façade (Q<10 dB). Questionnaire data were linked to individual exposure assessment based on detailed spatial data (GIS) and standard modeling techniques. Annoyance was less likely (OR(Q) (>10)<OR(Q) (<10)) in the subgroup with relatively quiet façade compared to the subgroup without relatively quiet façade. The difference in response between groups seemed to increase with increasing Q and L(den). Results indicate that residents may benefit from a quiet façade to the dwelling.