Due to the continuous intensification of human activities in the ocean, the frequent outbreaks of red tide have caused great harm to the marine environment and ecology. Thus, the rapid detection and monitoring of red tide become particularly important. At present, the main monitoring methods depend on artificial and buoy data, as well as optical satellite remote sensing. However, these methods may not be able to effectively deal with the characteristics of red tide bloom, such as suddenness and unpredictability. The global navigation satellite system-reflectometry (GNSS-R) is an emerging technology that makes use of navigation signals as a remote sensing opportunity to obtain Earth surface information. GNSS-R has already been proved to be capable of retrieving sea surface parameters (e.g., dielectric constant and sea surface roughness) closely related to the outbreak of a red tide. In this article, we proposed a new method to estimate red tide density, which utilizes an all-new model associating GNSS-R observations with sea surface red tide density. This method can remove the weather influence and greatly decrease the revisit period, which is much longer for optical red tide remote sensing methods. The Landsat-8 near-infrared data and TechDemoSat-1 (TDS-1) GNSS-R data of a red tide outbreak in the sea off the Tsingtao coast in China are used to build and test the proposed method. The results demonstrate that the correlation coefficient is 0.73, and the root mean square error of retrieved red tide density is 2.84%, which shows that the GNSS-R technology shows great potential to perform the rapid and preliminary red tide monitoring and judgment.