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Kim, D.C., Chungwoon University, Hongseong, Republic of Korea; In, M.J., Chungwoon University, Hongseong, Republic of Korea
Journal of applied biological chemistry, 20/Dec , Volume: 56, Issue: 4Journal Article
Recently, alage has been considered as a potential anti-inflammatory source due to its distinctive habitat environemtn exposing to light and high oxygen concentration. In present study, anti-inflammatory effect of brown alga, Sargassum fulvellum ethanol extract, was examined . SFEE inhibited not only the production of nitric oxide and pro-inflammatory cytokines but also the expression of inducible nitric oxide synthase and cyclooxygenase 2 in LPS-induced RAW 264.7 cells without affecting cell viability . SFEE also suppressed the expression of nuclear factor kappa B , suggesting that SFEE could affect the expression of inflammation related cytokines and proteins through the regulation of NF-kB .
