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Mazzei, T; Marino, C; Nozzoli, F; Lopes-Pegna, A; Righi, R; Santomaggio, C; Lamanna, S; Periti, P
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 3, Issue: 1Journal Article
The authors investigated the activity of a combination of DDP 80 mg/m2 i.v. followed by VP16 50 mg/m2 on days 2-5 in bronchogenic carcinoma. Twenty-seven patients entered the study (10 small cell carcinoma, 9 squamous cell, 2 adenocarcinomas and 6 histologically undefined). Six patients evidenced partial response (22.3%); one patient (small cell) had complete remission. The toxicity of the regimen was scarce and well-tolerated by patients with an incidence of 88.8% alopecia, and 77.7% nausea and/or vomiting.
