Background:Hypertension with its related disorders is one of the most common health problems among the Iranian population. Hypertension can be developed by chronic stress and a positive association between stress and rs2596542 has been confirmed. Methods:A Total number of 112 hypertensive patients and 97 healthy individuals were involved in the study. Total blood genomic-DNA was extracted and PASA (PCR amplification of specific alleles) method was used to amplify MICA-rs2596542 polymorphic site. Different genotypes were visualized. The normality of the data was assessed and the binary logistic regression was used for OR and 95%CI calculations. Results:A-risk allele of rs2596542 increased the risk of hypertension development significantly (OR=1.734, p=0.006). Females were significantly more potent to hypertension development than males (OR=2.015, p=0.013). Risk-allele homozygotes (AA) showed a higher risk of hypertension development than GG (OR=2.132, p=0.020) and AG individuals (OR=3.206, p=0.006). Age adjustments at 70 years old, further increased the risk of hypertension development in GG (OR=3.772, p=0.011) and AG (OR=6.531, p=0.009) individuals. Conclusion:A-risk allele of rs2596542 could increase the risk of hypertension up to 3.2 folds and this risk could be upraised after sex and age adjustments.