This paper presents the results of a multiobjective optimization of integration of the Trombe wall in a typical residential building in Uzbekistan using a full factorial experiment. The following parameters were used as factors of the experiment: orientation of the southern wall of a typical building, thermal resistance of translucent fences, ratio of the surface area of the thrombus wall to the surface area of the building façade, and air flow rate through the Trombe wall. Calculations were made for the building with three levels of thermal protection under climate conditions of the city of Tashkent (Uzbekistan). The study object was a typical one-story three-room residential building. It has been revealed that the relative dominance of the factors within the studied range of factor values during the heating period is in the following order: orientation of the southern wall of the building, 4.56%; thermal resistance of translucent fencing, 58.21%; ratio of the surface area of the Trombe wall to the surface area of the building facade, 20.11%, and air flow rate through the Trombe wall, 17.12%. On average, the optimal combination of factors makes it possible to save from 11.1–23.5 to 68.1–93.7% of the annual specific energy consumption of the building during the heating period. Reductions in CO 2 emissions with the use of coal for building heating range from 2106 to 129 731 kg per year. Depending on the investment, the simplified payback period for the integration of the Trombe wall is 12.279 to 28.445 years. Regression equations are proposed for three levels of thermal protection of the study object, which makes it possible to determine the specific energy consumption for heating.