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Smoleń, Sabina; Wincenciuk, Aleksandra; Drapała, Olga; Gryko, Dorota
Synthesis (Stuttgart), 05/2021, Volume: 53, Issue: 9Journal Article
Abstract Vitamin B 12 plays a crucial role in enzymatic transformations. This natural compound proved also useful as a catalyst in numerous organic reactions. Commercial availability and lower cost than precious metal complexes, make cobalamin an attractive candidate for a broader use as a benign Co-catalyst. Herein, the vitamin B 12 -catalyzed dicarbofuntionalization of bromoalkenes with electrophilic olefins is reported leading to substituted pyrrolidines and piperidines in decent yields after only 15 minutes under light irradiation.
